选择题(每题1分,共30分)A型题: 每一考题有A、B、C、D、E最佳答案填入题干后括号内。
1( )A B C构D E2( )A BC D R质粒的细菌E F质粒的细菌3( )A B C LPS D E多糖4?( )A. 因宿主细胞内有相应抑制物B. 因宿主细胞DNA有关基因激活C. 因宿主细胞缺乏有关酶D. 因感染病毒有核酸缺失E. 因感染病毒抗原性转变5( )A B CD E6( )A Ames testB transformation testC fluctuation testD replica plating testE Widal test7( )A B C DE8. : ( )A. 乙型溶血性链球菌B. 金黄色葡萄球菌C. 淋病奈瑟菌D. 肺炎球菌E. 脑膜炎奈瑟菌9. ( )A. 细胞病变效应B. 红细胞吸附C. 细胞代谢的改变D. 干扰现象E. 细胞培养液混浊10( )A B C DE11( )A StreptococcusB StaphylococcusC MeningococcusD GonococcusE Pneumococcus12( )A B C呈分枝生长D E13. ( )A B C磷脂D E14( )A. 鼠伤寒沙门菌B. 志贺菌C. 蜡样芽胞杆菌D. 希氏沙门菌E. 产肠毒素的金黄色葡萄球菌15分离培养病原( )A B C择鉴别培养基D E16( )A RNA和DNAB C格细胞内寄生D E17( )A B C胞壁D E18? ( )A B C分生孢子D E19The main infection source of epidemic type B encephalitis virus is: ( )A. patientB. health carrierC. young pigD. culicineE.louse20The main type of infection caused by Poliovirus is( )A inappareent infectionB acute infectionC chronic infectionD latent infectionE slow virus infection21At an office visit, a 38-year-old man complains of jaundice黄疸, dark urine,anorexia厌食, abdominal pain, and malaise不适. Serologic tests are positive for bothHBeAg and HBsAg. Which statement most accurately describes the virus responsiblefor these findings? ( )A. Its genome is a messenger RNA (mRNA) that encodes a polyprotein.B. Its genome is linear double-stranded DNA.C. Its genome is RNA, but it replicates through a DNA intermediate.D. Its replication requires a helper virus.E. Its replication requires an RNA-dependent DNA polymerase.22. Which step in viral replication is inhibited by protease inhibitor? ( )A. PenetrationB. UncoatingC. TranscriptionD. ReplicationE. Viral assembly23. A 48-year-old man has been receiving blood products for hemophilia血友病since childhood. He is now suffering from a low-grade fever, weight loss, thrush鹅口疮, serious bouts of diarrhea, and symptoms of pneumonia. A deficiency in theproduction of which substance would be most pronounced in this patient? ( )A. Complement componentsB. Immunoglobulin G (IgG)C. Interferon-alpha (IFN-α)D. Interferon-gamma (IFN-γ)E. Interleukin-1 (IL-1)24 A neonate is born with a small head, intracerebral calcification脑内钙化, rash,and swollen liver and spleen. Cells with a basophilic nuclear inclusion body are obtainedfrom the patient’s urine, which condition describes the most prevalent consequenenceof adult infection with this agent? ( )A. Immunosuppression and susceptibility to opportunistic diseasesB. Mild arthritic condition with a fine lacy rashC. Mononucleosis with production of antibody to sheep red blood cellsD. No serious, definable disease symptomsE. Pharyngoconjunctivitis咽结膜炎25 A virus isolated from a patient with liver disease is detergent去污剂-sensitive,and its genome is infectious, Which virus do these findings describe? ( )A. EchovirusB. Hepatitis A virusC. Hepatitis C virusD. Hepatitis E virusE. PapillomavirusX型题: 每一考题有A、B、C、D、E案填入题干26( ) A毒B CD E ECHO病毒27SARS( )A B敏感C D方法E SARS28? ( )A20%肥皂水清洗伤口B70%酒精及碘酒涂擦伤口C D病毒血清E29? ( )A B C曲霉D E浆菌30. 下列哪些病原体感染后主要依赖细胞免疫发挥抗感染作用?( )A B C结核分枝杆菌D E0.5101细菌细胞壁特有的化学成分是__________真菌细胞壁特有的化学成分是__________。
2R质粒由和和。
3一般只在局部繁殖而不进入血流引起菌血症的细菌有_____________和___________一般只在局部增殖而不进入血流引起病毒血症的病毒有____________和__________等。
4与宫颈癌发生密切相关的病毒主要是______________和______________。
5. 90%以上金黄色葡萄球菌均存在一种能与IgG的Fc段结合的抗原__________。
6鉴别肠杆菌科致病菌与非致病菌常选用的生化试_____________7. 列举3种基因组分节段的RNA_____________________________________。
8. 列举3_________________________和_____________。
三、名词解释(每题318分)1.mesosome2. high frequency recombinant3. dysbacteriosis4. Dane particle5. Weil-Felix reaction6. subacute sclerosing panencephalitis520123HIV进入靶细胞的机制。
4PrPc 和PrPsc的主要区别。
五、论述题22 1. 以举一例阐述其致病机制。
(10分)2.特性、致病性和药物敏感性等方面的差异。
(12分)11. B 2 . A 3. C 4. C 5. E 6. A 7. C 8. B 9. E 10. C 11. B 12. E 13. C 14. B 15. C 16. C 17. A 18. A 19. C 20. A 21. E 22. E 23. D 24. D 25. C 26. ACDE 27. ABCE 28. ABDE 29. ABCD 30. ACDE0.51几丁质(纤维素)2耐药决定因子性菌毛耐药性3白喉棒状杆菌(肉毒梭菌)HPV(狂犬病毒,流感病毒)4HPV HSV-25SPA67轮状病毒汉坦病毒8流行性乙型脑炎病毒汉坦病毒三、名词解释(每题318分)1. mesosome兰阳性细菌。
线粒体的作用。
2. high frequency recombinantF色体一起复制。
整合有F故称之高频重组菌。
3. dysbacteriosis4. Dane particle存在于HBV感染者血液中的结构完整、有感染性的HBV42nm。
由Dane Dane颗粒。
5. Weil-Felix reactionOX19和OX2OX19和OX2及OX伤寒和恙虫病的辅助诊断。
6. subacute sclerosing panencephalitis亚急性硬化性全脑炎。
是麻疹病毒感染所致的一种晚期中枢神经系统7后昏迷死亡。
四、简答题5201.1无热原质水。
2的致病性密3452长繁殖产生痉挛毒素而致病。
髓前角运动神至运动神经元梢从而进入中为锌内肽酶裂性中间神经元和RenShaw使肌肉痉挛而引起破伤风的特有症状。
3HIV进入靶细胞的机制。
HIV病毒体的包膜糖蛋白gp120与靶细胞膜上的受体CD4分子gp120CXCR4或CCR5与辅受体gp41细胞膜发生4PrPc 和PrPsc的主要区别。
PrPc PrPscMolecularconfiguration3α-helix(42%)2 β-sheet(3%)2α-helix(30%)4 β-sheet(43%)Pattern Monomer or dimer Polymer (fibrils) Location in or oncellsCytoplasmic membrane Cytoplasmic vesicles and extracellular milieuhost Normal and infectedhumans and animalsInfected humans and animalsProtease k resistance No Yes Pathogenicity No Yes Infectivity No Yes五、论述题221.10细菌淋病奈瑟菌淋病螺旋体梅毒螺旋体梅毒支原体溶脲脲原体人型支原体生殖器支原体泌尿生殖道感染衣原体沙眼衣原体泌尿生殖道感染性病淋巴肉芽肿4.52.学特性、致12流感病毒的结构由核心和包膜两部分组成。