To introduce chemical actions, courses and reactions in living systems, that is Metabolism.
Contents of biochemistry
Static biochemistry
Protein Enzyme Carbohydrate Lipid Nucleic Acid Vitamin Hormone
Chapter 1 Chapter 2 Chapter 3
Chapter 4
Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9
Introduction to Biochemistry Waters Amino Acids and Primary Structures of Proteins Proteins: Three-Dimensional Structure and Function Properties of Enzymes Mechanisms of Enzymes Carbohydrates Lipids and Membranes Coenzymes and Vitamins
1.1 Brief history of Biochemistry
Period 1 Origin Phase ——the late century 18.
Period 2
Developing Phase——From the forepart to 40s of century 20.
Period 3
1780s Antoine Laurent Lavoisier (French): Combustion of a candle is similar to the “respiration ”of animals, as both need O2 . For the first time a physiological process was explained with reference to a nonliving mechanism. Disaffirming “The Phlogization
Static part :
To introduce structure and function of biomolecules (proteins, nucleic acids, carbohydrates, lipids etc.)
Dynamic part :
Rapid Development Phase——From 1950s to present.
Period 1
Origin Phase —— Modern Biochemistry was born in the late century 18 as the development of Chemistry and Physiology.
Biochemistry
Yongge Wu
School of Life Science National Engineering Laboratory for Aids Vaccine
Jilin University
What is Biochemistry ?
➢Biochemistry is the study of the
❖In 1838, J.J.Berzelius (Sweden chemist) named the term “Protein” which was from Greek “proteios”, meaning “most important”.
But he theorized “Vitalism theory”.
❖ In 1828 ， F.WÖ hler (Germany Chemist，1800-1882）showed by synthesizing urea from ammonium cyanate that compounds found in living organisms could be made in the laboratory from inorganic substrances.Accordingly,he rejected the “Vitalism theory”
molecules and chemical reactions of life.
➢It is the discipline that uses the principles and language of chemistry to explain biology at the molecular level.
Dynamic biochemistry
Metabolism and energy Carbohydrate metabolism Lipid metabolism Protein metabolism Nucleic acid metabolism Genetic information transmission
Chapter 1 Introduction to Biochemistry
1.1 Brief history of biochemistry 1.2 What are the questions for
biochemists to answer? 1.3 Biochemistry and other disciplines. 1.4 Application of biochemistry 1.5 Basic properties of living systems
The Textbooks
➢Principles of Biochemistry (3rd Edition)
H.R.Horton等主编，科学出版社 2003.4 ➢生物化学（第三版）
王镜岩、朱圣庚等主编，高等教育出 版社 2002.9
Contents of Biochemistry (1)
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