N+N Pt NNCl ClH 3Ccat:CH 4O 2CH 3OH2+1/2Bar-Nahum I. et al.,J.Amer.Chem.Soc., 126 10236(2004)Metathesis of alkene (Olefin metathesis)Yves Chauvin(法)Robert H. Grubbs(美)Richard R. Schrock(美)RR'C CRR'R''R'''C CR''R'''CRR'cat.+M []C6H5O O C6H5RuCl(CO)NTsNTsH2C CH2+2000<MW<50000C1398H1298(127个苯乙炔单体,直径12.5nm)Albatrossenes: cleft-containing polycylic aromatic hydrocarbon compds.1,3-bis(heptaphenyl-2-naphthyl)benzene1,3,5-tris(pentaphenyl)benzeneC 12H 25C 12H 25C 12H 25C 12H 25C 12H 25C 12H 25NN HBC-PhC 12 (共轭盘状LC)电子供体PTCBI 电子受体Schmidt-Mende L. et al ; Science , 293:1119 (2001)有机太阳能电池材料R'''R'R R''Spirobifluorene :electroluminescence (电致发光)R nR[]n polyparaphenylene Polyphenylene dendrimer聚苯撑热、氧化稳定；光(电)致发光、变色；苧烷(R)-桔味(S)-柠檬味CH2OH2CH2OH2Chloramphenicol 氯霉素O NH(R)-避孕药O NH(S)-心得宁N N O O OOHThalidomide(R)-N OO (S )-“When Drug Molecules Look in the Mirror ”c.,481(1996)natural products:TetrachloromertenseneBrClClCH3OCH3HOClClCl1998 Gribble G.W. Acc. 1998,31, 141OBrBrBr BrOCH3 Science 307, 917(2005)N O OO ClClvinclozolin Science 308, 1466(2005)N NOO H H RRR: H; BrindigoThyroxine(甲状腺素)Kendall E.C., 1915(分离)Harington C.R., 1927(结构、合成）3+CO 2-I I(H)HOCl ClClClClCl Cl ClCl Cl Cl Clb -六六六g -六六六DDTClCHClCCl 3ClCHClCH 21874~1900~19721939 Miller P.,(1948Nobel Prize)LD 50:250OCH 3CHCH 3OCCl 3DMDDTLD 50:6000LD 50(mg / Kg): 50%死亡率的剂量Cl ClOHCl ClClClCH 3OHCl CO 2HO OCl ClCl Cldioxin2,4,5-TSeveso, Italy(1976)C 6H 5CH 2Br C 6H 5COCH 2ClPOPs(P ersistent O rganic P ollutants)ClCl ClOdieldrin(狄氏剂)Chlordane (氯丹) Aldrin(艾氏剂)endrin (异狄氏剂)DDT;Heptachlor(七丹) Hexachlorobenzene(六氯苯)Mirex(灭蚁灵)camphechlor(毒杀酚) polychlorinated biphenyl (多氯联苯) Dioxinsfurans (呋喃)乾洗剂:煤油(1845); 四氯化碳(1897); 三(四)氯乙烯(1930~)织物保护剂:氟碳化物(Scotchgard, 3M)血袋:PVC轮胎; CD; 电话(脑)······RX可阻止有机汞的生成2Ca 10(PO 4)6(OH)2Ca 10(PO 4)6F 2OH-F-++2CaF 210206Ca 10(PO 4)6(OH)2+F-+PO 43-+OH-2羟基磷灰石氟磷灰石CFCi -C 4H 10；C 2H 4F 2/ CHF 2Cl; C 2HF 3Cl 2/ CHF 3/ c -C 6H 7Cl 5/ c -C 6H 8Cl 4O H 3C HOOHOOH HHH Nature 433,541(2005)冬眠信息素OHN OH2H RO 唾液酸R ：CH 2OH Neu 5GC 小鼠、狗、猪、猩猩细胞；R ：CH 3Neu5AC 人细胞雌甾醇雄甾醇O N PhO OHH TaxolNicolaou K.C.NatureHolton R.J. Amer. Chem. Soc.,OHgeraniol(香叶醇)HHOHleaf alcohol(叶醇)工业级全合成, 海绵提取物, 机理类似Taxol(+)-DiscodermolideMickel S.J.et al, Org. Process Res. Dev., 8,92,101,107,113,122(2004)CH CH 2NHC(CH 3)3H 2NCl ClOHHCl.Clenbuterol(羟甲叔丁肾上腺素;瘦肉精)CH CH 2NH 2OH HO HO肾上腺素OOHO H 3C HOOHOOH HHH Nature 433,541(2005)冬眠信息素SSOallicin(蒜素) Curr. Bio., 15, 929 (2005)S SThiarubrine l max= 345(10300)nmNN OOCO 2HCO 2HHO 2CH PQQ乙酸菌醇脱水酶辅酶，V B12发现后经55年得以确定的新V BNature 2003 425王浆酸9-ODA9-HDA HHCO 2H OHHCO 2H OHN CH 3N OHHMelatonin(褪黑激素; 脑白金;促进睡眠、改善耳鸣、减轻视差、减缓老化；不育、降体温、伤视力、引导高血压、糖尿病、忧郁、心脏疾病和免疫有障碍者加重)(CH 2)7CO 2CH3Pentacycloanammoxic 酸甲酯, 类脂化合物,厌氧铵-氧化细菌中发现.V. Mascitti, E. J. Corey , J.Am.Chem. Soc.,126, 15664(2004)N i Bu HPrPrCH 3i Bu N O isolated from Anacyclus pyrethrumOCH2CH2N N麻醉弹用: Fentanyl; 芬太奴O OOMorphine R=R’: HR'OCodeine R’:CH3; R: HHeroine R=R’:COCH3 ON CH3HPoppy,Papaver somniferumN •An aromatic ring•Attached to a quaternary carbon•Attached to two more carbons•Attached to a tertiary amineC2H5O2C NPh N Omeperidine methadoneOH OHC HCH2NHCH3Epinephrine肾上腺素NHH CH3Koumine钩吻素子N HCl epibatidinedendrobineN OCH3OCH3CH3CH3罂粟碱CH 2CHCH 2N S Allyl isothiocyanate (芥末味)L-tricholomic acid (口蘑氨酸)N 2-3+HN S N SN N O O O O tetramine 毒鼠强杀鼠灵毒鼠膦O O O OH C N P S Cl Cl CH 3HN HNH2 NH2NHNHH O渗入头发聚合NN NH2 H2HH H O。