in，on ，at，by ，of ，with 介词区别与用法in用在年月季节前，还有上午、下午等固定习语里at用于传统的节日前，如at Christmas等；还有固定词组：at noon, at night;在点时间前用at 如at 7.15on 用于具体的日期前，星期几，几号，包括那天的上午下午晚上等，如on Friday afternoon with:一、with表拥有某物Mary married a man with a lot of money .马莉嫁给了一个有着很多钱的男人。
I often dream of a big house with a nice garden .我经常梦想有一个带花园的大房子。
The old man lived with a little dog on the lonely island .这个老人和一条小狗住在荒岛上。
二、with表用某种工具或手段I cut the apple with a sharp knife .我用一把锋利的刀削平果。
Tom drew the picture with a pencil .汤母用铅笔画画。
三、with表人与人之间的协同关系make friends with sb talk with sb quarrel with sb struggle with sb fight with sb play with sb work with sb cooperate with sb I have been friends with Tom for ten years since we worked with each other , and I have never quarreled with him . 自从我们一起工作以来，我和汤母已经是十年的朋友了，但我们从没有吵过架。
四、with 表原因或理由John was in bed with high fever .约翰因发烧卧床。
He jumped up with joy .他因高兴跳起来。
Father is often excited with wine .父亲常因白酒变的兴奋。
五、with 表“带来”，或“带有,具有”，在…身上，在…身边之意The girl with golden hair looks beautiful .那个金头发的女孩看起来漂亮。
The famous director will come to the meeting with the leading actor and actress .那个有名的导演将带着男女主角来到会场。
A storm with a hurricane has come onto its way .带有飓风的风暴要来了。
Do you have money with you .身上带着钱吗？Take the umbrella with you in case it rains .随身带伞，以防下雨。
六、with表想法，信念，态度与…一致I agree with you on how to deal with it .关于此事如何处理，我同意你的看法。
I believe with the headmaster that a good teacher should not only teach a student what to learn but also how to learn it . 我相信校长所说，一个好老师不但教学生学什么，而且应教学生怎么去学。
七、with表示让步,“虽有,尽管”With all his money and fame, he is not happy .有着钱和名誉，他还是不快乐。
With good teachers and warmhearted classmates ,the new comer feels lonely . 虽有着好老师和热心的同学，这个新来的还是感觉孤独。
八、with表同时，或同一方向，“随着”The temperature of cold-blooded animals change with the temperature of the surroundings .冷血动物的体温随着周围的环境的改变而变化。
The big ship is sailing with the wind .这个大船正随风向航行。
And with the last words , she turned away.随着最后一句话说完，他转身离开了。
九、with的复合结构表行为方式或伴随情况1、with + n/pron + adj. He left the room with the door open .门开着，他就离开了屋子。
Don’t talk with your mouse full .嘴里满是东西，不要说话。
2、with + n/pron + adv. With the radio on ,grandma slept deeply in the chair . 收音机开者，奶奶在椅子里沉沉的睡着。
With Tom away , I always feel lonely .汤母不在，我一直感觉孤独。
3、with + n/pron + done The fellow stood there with his hands crossed .这个家伙两手交叉，站在那里。
The peasants have a good harvest with all the crops got in .庄稼都收割了，农民们有了一个好收成。
4、with + n/pron + to do With this book to help you , you can finish your work as soon as possible .有这本书来帮忙，你能尽快完成工作。
With so many problems to settle ,the new manager was too worried to eat anything .有着太多问题去处理，新经理担忧的吃不下任何东西。
5、with + n/pron + n The old man looks down upon everyone ,with his son chairman of the 伴company .因为他儿子是公司的主席，这个老头瞧不起任何人。
He was taken to hospital with his legs a mass of bleeding flesh .他被抬到医院，他的腿血肉模糊。
6、with + n/pron + 介词短语The man left the meeting with a book in his hand .这个男人手里拿着书离开了会议。
The woman with a diamond necklace around the neck must be wealthy .那个脖子上带项链的女人一定很有钱。
十、with其他用法主要出现在一些常用词和习语中，记住其特定含义即可。
It is a long time not to get in touch with Tom.很长时间没有和汤母取得联系了。
Down with imperialism.该处with表人与人之间的协同关系Guo Zhenyuan, a researcher with the Beijing-based China Institute of International Studies,——与中国国际学术会议机构北京总部合作的研究人员郭振远EG：make friends with sbtalk with sbquarrel with sbstruggle with sbfight with sbplay with sbwork with sbcooperate with sbI have been friends with Tom for ten years since we worked with each other , and I have never quarreled with him .自从我们一起工作以来，我和汤母已经是十年的朋友了，但我们从没有吵过架。
of可表示人物的特性,籍贯,特性或出生等He is of Irish descend (ascent)People of obscure origin (humble /noble)Man of keen perception a man of moral integrityfrom有时也可以表示人物的特性,籍贯,特性或出生等He is from China.He comes from China.该处如果用of/from,意思一样Guo Zhenyuan, a researcher of/from the Beijing-based China Institute of International Studies,——来自中国国际学术会议机构北京总部合作的研究人员郭振远in比较强调在空间位置中in on at一. in,on在方位名词前的区别1. in表示A地在B地范围之内。
如：Taiwan is in the southeast of China.2. on表示A地与B地接壤、毗邻。
如：North Korea is on the east of China.二. at, in, on在表示时间上的区别1. at指时间表示：（1）时间的一点、时刻等。
如：They came home at sunrise （at noon, at midnig ht, at ten o’clock, at daybreak, at dawn）.（2）较短暂的一段时间。
可指某个节日或被认为是一年中标志大事的日子。
如：He went home at Christmas （at New Year, at the Spring Festival, at night）.2. in指时间表示：（1）在某个较长的时间（如世纪、朝代、年、月、季节以及泛指的上午、下午或傍晚等）内。
如：in 2004, in March, in spring, in the morning, in the evening, etc（2）在一段时间之后。
一般情况下，用于将来时，谓语动词为瞬间动词，意为“在……以后”。
如：He will arrive in two hours.谓语动词为延续性动词时，in意为“在……以内”。