• 由水热法合成均匀的不同纵横比和表 -替代HAP纳米管。少量 面性质的F -加入HAP可以得到单晶纳米管。 3%F 在合成单晶纳米管过程中加入PEG和 油酸可以得到双亲性HAP纳米管。
合成方法
4ml油酸和0.5g十八胺/ 0.5 g PEG (20000, MW) 溶入16ml乙醇
+
Ca(NO3)2.4H2O（0.5g/7.5ml去离子水） NaF（0.003-0.025 g / 5 ml去离子水） Na3PO4.12H2O（0.5g/7.5ml去离子水）
The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy
Chun-Han Hou a,b, Sheng-Mou Hou a,c, YuSheng Hsueh a, Jinn Lin c, Hsi-Chin Wu a, Feng-Huei Lin a,*
搅拌十分钟，放入 40ml高压釜中，90150 oC/200-220 oC， 十小时
抗炎类等药物缓释载体，并且还可以作为某些化
学反应的催化剂。
纳米羟基磷灰石文献综述
• 纳米HAP的 制备方法主 要有共沉淀 法、水热法、 溶胶-凝胶 法、仿生合 成和溶剂热 法等。
Supported Silver-NanoparticleCatalyzed Highly Efficient Aqueous Oxidation of Phenylsilanes to Silanols
organic solvents
Ag-HAP合成
Ca5(PO4)3(OH) Ca/P=1.68 2.0g
加入
AgNO3 6.7×10-3M 150ml
室温下搅 拌6小时
硼氢化钠还原
Ag-HAP
solid
Bioactive, luminescent and mesoporous europium-doped hydroxyapatite as a drug carrier Piaoping Yang a,b, Zewei Quan b, Chunxia Li b, Xiaojiao Kang b, Hongzhou Lian b, Jun Lin b,*
• 在鼠模型活体内研究新型的磁性纳米 羟基磷灰石对癌症及恶性肿瘤的作用。 将纳米羟基磷灰石和磁性纳米羟基磷 灰石分别于磷酸盐缓冲液混合，注射 到肿块附近，将鼠放进具有高频和交 变磁场的感应加热器中。
磁性纳米羟基磷灰石的合成
HAP合成：
10Ca(OH)2+6H3PO4
→Ca
10(PO4)6(OH)2
Silanols
nucleophilic coupling partners in organic synthesis
synthesized
toxic reagents and vast waste
New idea
high catalitic activities
Ag-HAP
without
water as an oxidant
Chem. Eur. J. 2009, 15, 6973 – 6982
主要内容 主要内容
novel drug storage/ release systems
优点
1.加强生物药效 2.高功效 3.安全性 4.可控性al forms of dosage
biocompatible
Takato Mitsudome, Shusuke Arita, Haruhiko Mori, Tomoo Mizugaki, Koichiro Jitsukawa, and Kiyotomi Kaneda* Angew. Chem. Int. Ed. 2008, 47, 7938 –7940
Gold Supported on Hydroxyapatite as a Versatile Multifunctional Catalyst for the Direct Tandem Synthesis of Imines and Oximes
osteoconductive HAP nontoxic
good properties
noninflammatory
drug carriers
• Therefore,the design and development of luminescence functionalized HAP with nano-sized and mesoporous characteristics should be able to reach this goal. • Herein,they propose the one-step synthesis of novel luminescence functionalized mesoporous HAP materials by droping Eu3+ during the synthesis of mesoporous HAP,resulting in the formating of multifunctional materimal.
+18H2O
磁性HAP合成：
加入FeCl2.4H2O,PH=8.5,搅拌2小时陈化10小时，洗涤， 冷冻干燥。Fe/Ca摩尔比为1.
结论
•
新合成的磁性纳米HAP表现出良 好的生物相容性和注射入皮下组织的 几乎无毒性，并且具有令人满意的热 效率。在两周内可以快速的治疗鼠的 结肠癌，肿块不再复发。
Monodisperse F-Substituted Hydroxyapatite Single-Crystal Nanotubes with Amphiphilic Surface Properties
文献汇报
主要内容
• • • • • 引言 仿生合成 晶体生长基本原理 羟基磷灰石 羟基磷灰石研究现状
引言
仿生合成
仿生合成
生物矿物合成--模板合成法
模板合成方法中， 模板只是提供一个支 架让不同材料在一定 位置形成纳米材料， 其结构与模板的形状 互补，所以可以合成 一些一般方法很难合 成的纳米结构或其它 复杂有序的超级结构。 双亲嵌段共聚物包含 一个与无机矿物质表 面强烈作用的亲水段 (绑缚嵌段)和另外一 个作用很弱但可以提 高水中溶解性的亲水 段 (溶剂化嵌段).
a Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan b Department of Orthopaedic Surgery, Taiwan University Hospital, Yun-Lin Branch, Yun-Lin County, Taiwan c Department of Orthopaedic Surgery, Taiwan University Hospital, Taipei, Taiwan Biomaterials 30 (2009) 3956–3960
• Junfeng Hui,‡ Guolei Xiang,† Xiangxing Xu,† Jing Zhuang,† and Xun Wang*,†
†Department of Chemistry, Tsinghua University, Beijing 100084, People’s Republic of China, and ‡R&D Center of Biomaterial and Fermentation Engineering, Shaanxi Key Laboratory of Degradable Biomedical Materials, Department of Chemical Engnineering, Northwest University, Xian 710069, People’s Republic of China Inorg. Chem. 2009, 48, 5614–5616
Hao Sun, Fang-Zheng Su, Ji Ni, Yong Cao,* He-Yong He, and Kang-Nian Fan Angew. Chem. Int. Ed. 2009, 48, 4390 –4393
主要内容
building blocks for siliconbased polymeric materials
Multifunctional Hydroxyapatite Nanofibers and Microbelts as Drug Carriers
Zhiyao Hou, Piaoping Yang, Hongzhou Lian, Lili Wang, Cuimiao Zhang, Chunxia Li, Ruitao Chai, Ziyong Cheng, and Jun Lin*[a]
• This material is hierarchically structured and exhibits a nanoscale rodlike,mesoporous,crystalline structure, which is suitable for drug(IBU) release as a drug carrier.Especially, it exhibits strong red luminscence even after loading of drug molecules,and the PL intersity increases with the cumulative released amount of IBU,which can be easily tracked and monitored in the drug release process by the change of PL emission intersity.