实验三：外文（数据库）信息资源的检索（报告）专业：法学班级：******** 学号：111********5姓名：***一、实验目的：１．了解外文信息资源的概况及图书馆数据库的购置状况；２．掌握相关外文信息资源的检索技术与检索方法。
二、实验内容：1．S p r i n g e r数据库的收录特点与使用方法2．网络全文数据库E B S C O h o s t检索。
3．万方数据检索三、实验题目：同实验一查阅某一著者的文献四、实验要求：１．利用“S p r i n g e r数据库”检索你所选课题的检索2000年以来的相关的英文期刊论文的摘要及全文一篇（将论文正文第一页第一段下载）（1）提示：检索思路（期刊论文为例）http://202.199.233.12→点“”→点“SpringerLink”→请选择检索范围（文献类型：期刊）→论文题名（用截词检索方法输入一英文检索词）→显示检索结果→点击某一篇论文→显示摘要（注意判断是否原文为英文，是否为2000以后收录的期刊论文）。
(2)检索结果①期刊论文：论文名：Effect of Polysorbate 80 Quality on Photostability of a Monoclonal Antibody著者名Swita R. Singh jian ao刊名：AAPS PharmSciTech年：2012 卷： 1 期： 2 刊载页码： 69-76摘要（粘贴此处）：Polysorbate 80 is one of the key components of protein formulations. It primarily inhibits interfacial damage of the protein molecule due to mechanical stress during shipping and handling. However, polysorbate 80 also affects the formulation photostability. Exposure to light of polysorbate 80 aqueous solution results in peroxide generation, which in turn may result in oxidation of the susceptible amino acid residues in the protein molecule. The purpose of this study was to determine if the photostability of our proprietary IgG1 monoclonal antibody formulation containing polysorbate 80 is affected by the quality (grade/vendor) of polysorbate 80. Following four types of polysorbate80 were tested: (1) Polysorbate80 Super-Refined, Mallinckrodt Baker, (2) Polysorbate 80 NF, Mallinckrodt Baker, (3) Polysorbate 80 NF, EMD Chemicals, and (4) Ultra-pure Polysorbate 80 (HX), NOF Corporation. The samples were exposed to light as per ICH guidelines Q1B. The results of the study show that photostability of the antibody formulation is indeedaffected by the quality of polysorbate 80. This study underscores the importance of carefully choosing the quality of polysorbate 80 to ensure the robustness of formulation.论文第一页第一段正文为（粘贴此处，按照一般格式要求编辑文档）：Although it is widely agreed that surfactants such aspolysorbates enhance the stability of protein formulations,very limited effort has beendirected towards studying theeffect of the surfactant quality on the protein drug productstability. The purpose ofthis study was to evaluate the effectof polysorbate 80 quality on the photostability of IgG1 monoclonalantibody formulation. The quality difference in polysorbate80 from different supplier and grade may arise due tothe differences in their manufacturing and purification processes.Protein formulations are susceptible to interfacialdamage (1). The interfaces protein molecules may encounterin a formulation during bio-processing andin final dosage form,may be categorized into air–water interface (2), ice–waterinterface (3), and solid interfaces (4). Protein aggregationresulting from mechanical stress, mixing, freeze thawing, etc., is attributed to protein adsorption on the interfaces.Surface tension forces at the interfaces cause aggregationofthe adsorbed protein by affecting structural integrity ofthe protein molecules that populate the interfacial region②图书：书名：Studies on Action Mechanism of Acrocidal Activity of Extracts of Pharbitis purpurea Seeds against Tetranychus cinnabarinus著者名：Yubo Liu and Yan Wang出版社：Springer Berlin / Heidelberg出版年： 2012 版次： 12.“万方数据”检索你所选课题的检索2000年以来的相关的英文期刊论文的摘要及全文一篇（将论文正文第一页第一段下载）。
(1)提示：利用“万方数据”检索思路http://202.199.233.12→点“万方数据”→“点击链接进入”→请选择检索范围（文献类型：期刊）→论文题名（用截词检索方法输入一英文检索词）→显示检索结果→点击某一篇论文→显示摘要（注意判断是否原文为英文，是否为2000以后收录的期刊论文）。
(2)检索结果①期刊论文：论文名：Magnetoelastic biosensor for the detection of Salmonella typhimurium in food products著者名：Rajesh Guntupalli ao jian刊名：Sensing and Instrumentation for Food Quality and Safety年：2009 卷： 28 期：1 刊载页码： 3-11摘要（粘贴此处）：Abstract:In this article, a magnetoelastic sensor immobilized with polyclonal antibody for the detection of Salmonella typhimurium in food products is described. The remote query nature of magnetoelastic sensors enables the detection of bacterial species in sealed and opaque containers. Bacterial bindingto the antibody on the sensor surfaces changed the resonance parameters, and these changes were quantified by the shift in the sensor’s resonance frequency. Response of the sensors to increasing concentrations(5 × 101–5 × 108 cfu/ml) of S. typhimurium in three different food products (water, fat-free milk and apple juice)was studied and similar responses were observed. These results were also further ascertained by Scanning Electron。