本科毕业设计（论文）题目年产30万贴烧伤敷料车间工艺设计姓名刘苗专业高分子材料与工程学号 ********指导教师高光辉长春工业大学化学工程学院2017年 3月27 日摘要传统烧伤敷料吸液量不够大,需要厚厚包扎并经常更换，敷料在吸液后易干燥,并与伤口发生粘连而造成二次创伤,又不便使用等缺点,所以逐渐被其它敷料代替。

水凝胶是一种含有大量水分的亲水性的网状高分子溶胀体 ,具有良好的吸水性，表面光滑 ,生物相容性好 ,所以在生物医学工程领域得到了广泛的研究和应用。

水凝胶敷料能与不平整的创面紧密帖合但不粘连 ,减少细菌滋生的机会。

本设计对水凝胶烧伤敷料的生产进行了工艺设计。

设计内容主要包括：配方的选取、物料衡算、车间工艺设计、生产设备的选取、生产车间的设计等。

并对涉及的聚合方法进行了介绍，对公用系统进行了简单说明。

除此之外，在本设计中绘制了工艺流程图、车间布置图以及主要设备图。

关键词：水凝胶烧伤敷料合成高分子合成敷料理想敷料AbstractTraditional burns dressing is not large enough, need thick dressing and frequent replacement, dressing in the liquid after the easy to dry, and the wound adhesion caused by secondary trauma, and inconvenience to use and other shortcomings, so gradually replaced by other dressings. Hydrogel is a hydrophilic high-molecular polymer swelling body containing a lot of water. It has good water absorption, smooth surface and good biocompatibility. Therefore, it has been widely studied and applied in biomedical engineering. Hydrogel dressings can be closely tied with uneven creatures but not sticky, reducing the chance of bacterial growth.This design has been crafted for the production of hydrogel burn dressings. The design content includes: the selection of recipe, material accounting, workshop process design, production equipment selection, production workshop design. The introduction of the polymerization method is introduced, and the common system is briefly described. In addition to this design in the design of the process flow chart, the layout of the workshop and the main equipment map.Keywords: Hydrogels；Burn dressings；Synthetic polymer；Synthetic dressings；Ideal dressing.目录第一章绪论----------------------------------------------------------------------------------------------------------------------- 4 1.1水凝胶烧伤敷料的简要概述 -------------------------------------------------------------------------------------- 4 1.2水凝胶烧伤敷料的发展现状 -------------------------------------------------------------------------------------- 4 1.3几种常用敷料的对比 ------------------------------------------------------------------------------------------------ 51.3.1传统敷料和生物敷料 ------------------------------------------------------------------------------------------ 51.3.2合成敷料 ----------------------------------------------------------------------------------------------------------- 51.3.3水凝胶敷料-------------------------------------------------------------------------------------------------------- 6 1.4理想敷料应该具备的功能------------------------------------------------------------------------------------------ 7 1.5作为创伤敷料设计水凝胶的原则 ------------------------------------------------------------------------------- 7 1.6水凝胶创伤敷料课题研究的意义 ------------------------------------------------------------------------------- 7第二章配方设计 ---------------------------------------------------------------------------------------------------------------- 82.1主要原料----------------------------------------------------------------------------------------------------------------- 82.1.1对苯二酚 ----------------------------------------------------------------------------------------------------------- 82.1.2 氰基丙烯酸丁酯 ------------------------------------------------------------------------------------------------ 92.1.3丙二醇 -------------------------------------------------------------------------------------------------------------- 92.1.4壳聚糖 ------------------------------------------------------------------------------------------------------------ 102.1.5羧甲基纤维素钠 ----------------------------------------------------------------------------------------------- 122.1.6明胶---------------------------------------------------------------------------------------------------------------- 14 2.2聚合方法 --------------------------------------------------------------------------------------------------------------- 152.2.1悬浮聚合 --------------------------------------------------------------------------------------------------------- 162.2.3悬浮聚合工艺 -------------------------------------------------------------------------------------------------- 162.2.4悬浮聚合的优缺点-------------------------------------------------------------------------------------------- 17 2.3配方的设计 ----------------------------------------------------------------------------------------------------------- 17第三章物料衡算 -------------------------------------------------------------------------------------------------------------- 183.1概述 --------------------------------------------------------------------------------------------------------------------- 18 3.2物料衡算基准 -------------------------------------------------------------------------------------------------------- 18 3.3总需料量的计算----------------------------------------------------------------------------------------------------- 18 3.4物料衡算--------------------------------------------------------------------------------------------------------------- 19第四章设备选型------------------------------------------------------------------------------------------------------------- 214.1设备的选择原则----------------------------------------------------------------------------------------------------- 214.1.1 选型的原则----------------------------------------------------------------------------------------------------- 214.1.2 设备的分类和选型------------------------------------------------------------------------------------------- 224.1.3 设备选型工艺参数内容 ------------------------------------------------------------------------------------ 22 4.2非定型设备的选取 ------------------------------------------------------------------------------------------------- 234.2.1 储罐的选型及工艺设计 ------------------------------------------------------------------------------------ 23 4.3定型设备的选取----------------------------------------------------------------------------------------------------- 254.3.1 涂布机 ----------------------------------------------------------------------------------------------------------- 264.3.2称量设备 ----------------------------------------------------------------------------------------------------------274.3.3 包装设备 ---------------------------------------------------------------------------------------------------------274.3.4喷码机 ------------------------------------------------------------------------------------------------------------ 284.3.6高温干热灭菌器 ----------------------------------------------------------------------------------------------- 29第五章工艺流程------------------------------------------------------------------------------------------------------------- 295.1概述 --------------------------------------------------------------------------------------------------------------------- 29 5.2工艺流程图 ----------------------------------------------------------------------------------------------------------- 30第六章公用系统 -------------------------------------------------------------------------------------------------------------- 316.1纯化水系统------------------------------------------------------------------------------------------------------------ 316.1.1纯化水制备流程 ----------------------------------------------------------------------------------------------- 316.1.2制药用纯化水设备要求 ------------------------------------------------------------------------------------- 31 6.2空调系统 --------------------------------------------------------------------------------------------------------------- 326.2.1概述---------------------------------------------------------------------------------------------------------------- 326.2.2空调系统参数要求-------------------------------------------------------------------------------------------- 326.2.3空调系统控制 -------------------------------------------------------------------------------------------------- 33 6.3配电系统 --------------------------------------------------------------------------------------------------------------- 346.3.1概述---------------------------------------------------------------------------------------------------------------- 346.3.2设计要求 --------------------------------------------------------------------------------------------------------- 34第七章车间布置设计------------------------------------------------------------------------------------------------------ 357.1概述---------------------------------------------------------------------------------------------------------------------- 35 7.2车间设计的要求和原则 ------------------------------------------------------------------------------------------- 357.2.1要求---------------------------------------------------------------------------------------------------------------- 357.2.2原则---------------------------------------------------------------------------------------------------------------- 367.3.1 设备布置的基本要求 --------------------------------------------------------------------------------------- 37参考文献 ------------------------------------------------------------------------------------------------------------------------ 40第一章绪论1.1水凝胶烧伤敷料的简要概述皮肤是人体的重要器官 ,由表皮和真皮两部分组成 ,具有重要的物理、化学及生物屏障功能。