山东理工大学毕业论文手册学院化学工程学院系化学工程专业化学工程与工艺班级1203学生姓名高振东学号12110802090指导教师宋沙沙职称讲师山东理工大学教务处编印二〇一六年六月毕业设计（论文）自二〇一六年二月至二〇一六年六月共十七周毕业论文任务书（理工）学院化学工程学院学生姓名高振东专业化学工程与工艺班级1203班学号12110802090指导教师宋沙沙职称讲师课题名称凝胶微球的制备及其在分子识别中的应用起止日期自2016年2月29日起至2016年6月24日一、课题来源：论文《高伸缩性和坚韧的水凝胶》二、课题目的要求：采用海藻酸钠和氯化铜制备凝胶微球，测试其动态力学性能和微观结构。

通过将凝胶中的铜离子还原研究其在分子识别中的应用。

培养学生良好的科研习惯，提高学生的实验能力和科研能力以及解决实际生产实践问题的能力.三、主要研究内容：⒈通过海藻酸钠和氯化铜制备凝胶微球。

⒉凝胶微球的动态力学性能和微观结构。

⒊硼氢化钠还原铜离子。

四、研究方法及主要论点、论据（或研究目标）：采用海藻酸钠和氯化铜制备凝胶微球，测试其动态力学性能和微观结构。

通过将凝胶中的铜离子还原研究其在分子识别中的应用。

培养学生良好的科研习惯，提高学生的实验能力和科研能力以及解决实际生产实践问题的能力.五、分阶段指导性进度计划：第1-2周查阅相关类似体系的文献资料，写出文献综述。

第3-4周进行英语文献的翻译工作。

第5-6周海藻酸钠凝胶微球的制备。

第7-8周硼氢化钠还原凝胶微球中的铜离子。

第9-11周研究凝胶微球的动态力学性能和微观结构。

第12-14周对研究过程进行总结和撰写论文第14-15周制作PPT,准备毕业论文的答辩六、主要参考文献资料：[1]Osada Y, Gong J P. Soft and wet materials: Polymer gels . Advanced Materials,1998, 10:827-837.[2]Yoshida R, Uchida K, Kaneko Y. Comb-type Grafted Hydrogels with RpidDe-swellingResponse to Temperature-change . Nature, 1995, 374: 240-242.[3]Zhang X Z, Wu D Q, Chu C C. Synthesis, characterization and controlleddrugrelease of thermosensitive IPN-PNIPAAm hydrogels . Biomaterials, 2004, 25: 3793-3805.[4]Gong C, Qi T, Wei X. Thermosensitive polymeric hydrogels As drug deliveysystems .Current Medicinal Chemistry, 2013, 20: 79-94.[5]Li Z Q, Guan J J. Thermosensitive hydrogels for drug delivery . Expert OpiniononDrug Delivery, 2011, 8: 991-1007.[6]Chen S C, Wu Y C, Mi F L. A novel pH-sensitive hydrogel composed ofN,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. Journal of Controlled Release, 2004, 96: 285-300.[7]Brannonpeppas L, Peppas N A. Equilibrium swelling behavior of pH–swellinghydrogels . Chemical Engineering Science, 1991, 46: 715-722.[8]Qu X, Wirsen A, Albertsson A C. Novel pH-sensitive chitosan hydrogels:swellingbehavior and states of water . Polymer, 2000, 41: 4589-4598.[9]Naficy S, Spinks G M, Wallace G G. Thin, Tough, pH-Sensitive hydrogel filmswithrapid load recovery . Acs Applied Materials & Interfaces, 2014, 6: 4109-4114.[10]Z hao Y L, Stoddart J F. Azobenzene-based light-responsive hydrogel system.Langmuir, 2009, 25: 8442-8446.[11]L o C W, Zhu D F, Jiang H R. An infrared-light responsive graphene-oxideincorporated poly(N-isopropylacrylamide) hydrogel nanocomposite. Soft Matter, 2011, 7:5604-5609.[12]Y an B, Boyer J C, Habault D. Near infrared light triggered release ofbiomacromolecules from hydrogels loaded with upconversion nanoparticles .Journal of the American Chemical Society, 2012, 134: 16558-16561.[13]S ozeri H, Alveroglu E, Kurtan U. Magnetic hydrogel with high coercivity.Materials Research Bulletin, 2013, 48: 2751-2757.[14]L iu T Y, Hu S H, Liu K H. Preparation and characterization of smartmagnetichydrogels and its use for drug release. Journal of Magnetism andMagneticMaterials, 2006, 304: E397-E399.[15]Z hang Y L, Yang B, Zhang X Y. A magnetic self-healing hydrogel .ChemicalCommunications, 2012, 48: 9305-9307.[16]K im S Y, Shin H S, Lee Y M. Properties of electroresponsive poly(vinylalcohol)/poly(acrylic acid) IPN hydrogels under an electric stimulus . Journal of Applied Polymer Science, 1999, 73: 1675-1683.[17]K ulkarni R V, Biswanath S A. Electrically responsive smart hydrogels indrugdelivery: a review . Journal of Applied Biomaterials & Biomechanics, 2007, 5: 125-139[18]K ennedy S, Bencherif S, Norton D. Rapid and extensive collapse from electricallyresponsive macroporous hydrogels . Advanced Healthcare Materials, 2014,3: 500-507.[19]L in S B, Yuan C H, Ke A R. Electrical sensitivity and mechanical propertiesoffastresponsive PAMPS-PAA-PVA T-IPN hydrogels . Advances in Polymer Techn-ology,2013, 32: E20-E31[20]K ozlovskaya V, Kharlampieva E, Mansfield M L. Poly(methacrylic acid)hydrogelfilms and capsules: Response to p H and ionic strength, and encapsulation of macromolecules . Chemistry of Materials, 2006, 18: 328-336.[21]Z hang R S, Tang M G, Bowyer A. A novel pH- and ionic-strength-secarbox methyldextran hydrogel . Biomaterials, 2005, 26: 4677-4683.[22]L i H, Lai F, Luo R. Analysis of responsive characteristics ofionic-strength-sensitivehydrogel with consideration of effect of equilibrium constant by a chemo-electro-mechanical model . Langmuir, 2009, 25: 13142-13150.[23]L ee K Y, Mooney D J. Hydrogels for tissue engineering . Chemical Reviews,2001, 101: 1869-1879.[24]S hu X Z, Liu Y C, Palumbo F S. In situ crosslinkable hyaluronan hydrogelsfortissue engineering . Biomaterials, 2004, 25: 1339-1348.[25]H unt J A, Chen R, van Veen T. Hydrogels for tissue engineering and regenerativemedicine . Journal of Materials Chemistry B, 2014, 2: 5319-5338.[26]Q iu Y, Park K. Environment-sensitive hydrogels for drug delivery . Advanced DrugDelivery Reviews, 2001, 53: 321-339.指导教师（签字）：2016 年月日系主任（签字）：20 年月日注：本表由指导教师填写，经系主任审核后下发学生。