皮肤病与性病摇2010年6月第32卷第2期摇JDermatologyandVenereology,Jun2010,Vol郾32,No郾2摇摇摇摇·综述·肌内膜浸润CD8
+T淋巴细胞占绝对优势,这些浸润往往在非
变性的纤维周围和有时似乎也入侵纤维内。这表明,有一种免疫反应是针对肌纤维的。相比之下,血管周围浸润以CD4
+
T淋巴细胞为主和一些巨噬细胞,且有时也有B淋巴细胞。
这就提示了有一种免疫反应是以微血管为靶器官的。在PM和DM(但不包括IBM)可发现肌炎特异及非特异性自身抗体,支持了B淋巴细胞、CD4
+T细胞在IIM的作用[12]。在部
分患者尤其是能检测出自身抗体的患者发现与HLA-DRB1*0301,DQA1*0501,DQB1*0201有遗传相关性,进一步支
持了CD4
+T淋巴细胞在发病机制中的作用。
各学科的新的进展,可以帮助进一步了解免疫机制在IIM中的重要作用。总之,他们免疫系统在这些疾病表现了
复杂性,固有和适应性免疫系统都参与了IIMS,因此有必要不断完善或修改“既往的假说冶。近来关于最恰当和准确的诊断标准,就包括了组织病理学的重要性和免疫细胞的定位。其他,如自身抗体的分型可能也会成为疾病亚型分类的重要指标,这将有助于提高认识疾病的机制和从而改善治疗和预后。
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揖收稿日期铱2009-08-12白三烯及抗白三烯药物与皮肤病相关性的研究进展肖摇沙,陈德宇,杨西群(泸州医学院附属医院皮肤科,四川摇泸州摇646000)
摘要:白三烯作为一种重要的炎症介质参与了多种皮肤病的发生发展,抗白三烯药物对皮肤病的治疗也有一定的疗效。本文回顾了白三烯与相关皮肤病的文献,阐述了白三烯在皮肤病发展中的作用以及抗白三烯药物在皮肤病治疗中的应用。关键词:白三烯;皮肤病;发病机制;治疗;综述。
中图分类号:Q946郾48;R751摇摇文献标识码:A摇摇doi:10.3969/j.issn.1002-1310.2010.02.011Leukotriene,anti-leukotrienedrugsanddermatosis(Review)XIAOSha,CHENDe-yu,YANGXi-qun(DepartmentofDermatology,theaffiliatedHospitalofLuzhouMedicalCollege,SichuanLuzhou646000Chi鄄
na)
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