世界最杰出的生物医学论文千名生物学家（Faculty of 1000 Biology）和千名医学家（Faculty of 1000 Medicine）是英国BioMed Central出版集团，所建立的两个医学生物学论文数据库。
它是由美国哈佛大学和英国剑桥大学等近5000多名世界顶级生物医学同行专家，所推荐和评选出的世界医学和生物学的最新发表的论文所组成。
论文依据创新性、新理论、新发现、新技术、科学价值和实际应用前景等原则，从世界上几千种重要的医学生物学杂志，成千上万篇论文中，实时进行筛选和评定，评选出F1000因子，并进行分级排序，分为杰出(Exceptional 9分)、必读(Must Read 6分)和推荐(Recommend 3分)三个级别，并写有简短的评语。
再向医学生物学界进行推荐和发布，以提供世界上最重要、最优秀的生物医学论文信息和最新研究成果与发展趋势。
F1000只重视论文的实际科学价值和临床应用前景，不考虑期刊的状况和论文在何处发表，影响因子（I F）值也仅仅作为辅助参考指标。
被推荐出的论文不足SCI发表论文的千分之二，其中杰出的论文仅占所推荐论文的5%。
F1000还依据不同的科学领域，适时评选出最近和最受关注（Must-Viewed）的10篇最佳论文，称为“Top 10”，并不断更新。
此外还邀请世界上最知名和权威的领域科学家，编写生物医学最近的进展、评论和综述，刊登在“F1000 Reports上”。
F1000是一个新的医学生物学论文数据库，是一个新的生物医学论文评价工具，是一个新的医学论文评估的专家系统。
它不仅可以帮助我们来快速检索世界上最“杰出”、“必须阅读”和“值得推荐”的生物医学论文；还可以了解每篇发表论文的专家评价观点和意见，使我们可以节时、高效、全面认识和了解当今世界上生物医学最新研究成果和发展动向，引导和促进生物医学科学的发展。
研究论文能为F1000所收录和推荐，成为F1000“杰出”论文，代表着该论文的极高的科学水平和重要的科学价值。
目前我国每年被SCI收录的医学生物学论文已逾万篇，成为“论文大国”，但能为F1000收录为“杰出”的论文却寥寥。
以2009—2010年为例，在F1000收录和推荐出1017篇“杰出”论文中，中国只有11篇，其中还有4篇是台湾和香港的。
从2000—2010年F1000共评出近5000篇“杰出”论文，中国（包括台湾和香港）总共只有25有篇。
反应出我国现在医学生物学研究“跟”多“创”少，重“量”不重“质” ；一般资料性的工作多，有创新性、有实际应用价值、有重要理论和应用前景的论文少的潜在而深刻的危机。
我们必须在原始创新和实际应用上再上一层楼！我们要发表SCI论文，要发表高IF影响因子论文；我们更要多发表F1000“杰出”论文，发表创新性强，有重要理论价值和实际应用前景的科学论文，这才能成为真正的科技强国。
这里我们收集了2009－2010年心血管、肿瘤、细胞生物学、分子生物学、免疫学、神经科学等领域F1000的“杰出”论文供大家参考，更多的F1000论文，可在F1000Biology和F1000Medicine网站上搜索。
• Biochemistry• Bioinformatics• Biotechnology• Cancer Biology• Cardiovascular Biology• Cell Biology• Chemical Biology• Developmental Biology• Ecology• Evolutionary Biology• Gastrointestinal Biology• Genomics & Genetics• Immunology• Metabolic & Endocrine Science• Microbiology• Molecular Biology• Molecular Medicine• Neuroscience• Pharmacology & Drug Discovery• Physiology• Plant Biology• Renal Biology• Respiratory Biology• Structural Biology• Anesthesiology & Pain Management• Cardiovascular Disorders• Critical Care & Emergency Medicine• Dermatology• Diabetes & Endocrinology• Gastroenterology & Hepatology• Hematology• Infectious Diseases• Nephrology• Neurological Disorders• Oncology• Otolaryngology• Psychiatry• Public Health & Epidemiology• Research Methodology• Respiratory Disorders• Rheumatology & Clinical Immunology• Urology• Women's Health________________________________________F1000 Reportcell-A mover and a shaker'- 53BP1 allows DNA doublestrand breaks a chance to dance and unitecell-A virtual cycle- theory and experiment converge on the exit from mitosiscell-Aberrant mRNA transcripts and nonsense-mediated decaycell-Autophagy of intracellular microbes and mitochondria- two sides of the same coincell-Brd4 engagement from chromatin targeting to transcriptional regulation- selective contact with acetylated histone H3 and H4cell-Conformational changes in receptor tyrosine kinase signaling- an ErbB garden of delightscell-Destroy to create- E3 ubiquitin ligases in neurogenesiscell-Doing cell biology in embryos- regulated membrane traffic and its implications for cadherin biologycell-Epigenetic regulation of antigen receptor gene rearrangementcell-G-protein-coupled receptor structurecell-Induced pluripotent stem (iPS) cells- an up-to-the-minute reviewcell-Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancercell-Intracellular trafficking and signaling in developmentcell-LOV conquers (sm)All GTPasescell-Membrane deformation and separationcell-Microtubule motors- moving forward on many frontscell-Mitochondria and apoptosis- a quick take on a long viewcell-novel functions of the exocyst complex in polarized epithelia in animalscell-PARP inhibitors in BRCA1-BRCA2 germline mutation carriers with ovarian and breast cancercell-Plk4-SAK-ZYG-1 in the regulation of centriole duplicationcell-Putative functions of caspase-2cell-Recent advances in polyubiquitin chain recognitioncell-Recent advances in understanding Golgi biogenesiscell-Regulatory roles of the cadherin superfamilycell-Role of caspases and non-caspase proteases in cell deathcell-Roles of AD-cofilin in actin polymerization and beyondcell-Roles of the small GTPases RhoA and Rac1 in cell behaviorcell-Single-molecule dynamics of nuclear mRNAcell-Spindle checkpoint silencing- ensuring rapid and concerted anaphase onsetcell-Telomeric RNAs as a novel player in telomeric integritycell-The roles, mechanisms, and controversies of autophagy in mammalian biologycell-Transport vesicle uncoating- it's later than you thinkcell-Understanding lipid rafts and other related membrane domainscell-Vesicle coating and uncoating- controlling the formation of large COPII-coated carrierscell-When transcription meets recombinationecology-Characterizing changes in marine ecosystem servicesecology-Climate change and biodiversity conservation- impacts, adaptation strategies and future research directionsecology-Current themes and recent advances in modelling species occurrencesecology-Eco-evolutionary dynamics- intertwining ecological and evolutionary processes in contemporary time ecology-Evaluation of global change impacts on diffuse pollutionecology-Evolutionary impacts of fishingecology-Extinction risks from climate change- macroecological and historical insightsEcology-Modelling ecosystem services in terrestrial systemsecology-The consequences of human-driven ocean acidification for marine lifeecology-Toward understanding the effect of top predators on ecosystemsgenome-A direct measurement of crossing over in human prophase oocytesgenome-Advances in the genetics of primary torsion dystoniagenome-Applications of high-throughput sequencing to chromatin structure and function in mammalsgenome-Bioinformatic detection of horizontally transferred DNA in bacterial genomesgenome-CRISPR-Cas- an adaptive immunity system in prokaryotesgenome-Distinct disorders affecting the brain share common genetic originsgenome-Emerging technologies for the genomic analysis of cancergenome-Genetics of pulmonary arterial hypertension- do the molecular findings have translational value- genome-Hidden ribozymes in eukaryotic genome sequencegenome-how medical sequencing and network biology will enable personalized medicinegenome-Insulators- linking genome architecture to gene regulationgenome-Mapping chromatin conformationgenome-Pharmacogenetics of osteoporosisgenome-PRDM9 sticks its zinc fingers into recombination hotspots and between speciesgenome-Prediction of function in protein superfamiliesgenome-RecA-independent single-stranded DNA oligonucleotide-mediated mutagenesisgenome-Recent advances in RNA sequence analysisgenome-Retrotransposons and germ cells- reproduction, death, and diversitygenome-The application of massively parallel sequencing technologiesgenome-Ubiquitous antisense transcription in eukaryotes- novel regulatory mechanism or byproduct of opportunistic -NA polymerasegenome-When transcription meets recombination- a lesson from the human RECQ protein complexesimm-Antigen processing for MHC presentation by autophagyimm-inf-A novel mucosal RORt+NKp46+ cell subset is a source of interleukin-22imm-inf-Advances in understanding the interaction between the gut microbiota and adaptive mucosal immune responsesimm-inf-Alternative macrophage activation and the regulation of metabolismimm-inf-An update on pathobiologic roles of anti-glycan antibodies in Guillain-Barr茅syndromeimm-inf-B cell-targeted therapies in autoimmunity- rationale and progressimm-inf-Bacterial surface proteins and vaccinesimm-inf-Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion imm-inf-Do apicomplexan parasites hijack the host cell microRNA pathway for their intracellular development imm-inf-Duality in the Th17-Treg developmental decisionimm-inf-Electron transport chains of lactic acid bacteria - walking on crutches is part of their lifestyleimm-inf-Genetic reprogramming of host cells by bacterial pathogensimm-inf-Gut commensal flora- tolerance and homeostasisimm-inf-HIV vaccination- turning the spotlight on effector memory T cells as mucosal gatekeepersimm-inf-HIV-1 host interactions- integration of large-scale datasetsimm-inf-Latest advances in innate antiviral defenceimm-inf-Lessons from the failure of the adenovector HIV vaccineimm-inf-New templates for HIV-1 antibody-based vaccine designimm-inf-Ocular immune privilegeimm-inf-Recent insights into fatty acid acquisition and metabolism in malarial parasitesimm-inf-Recent strategies to identify broadly neutralizing antibodies against influenza A virusimm-inf-Regulation of the IgE responseimm-inf-The garden of antimicrobial delightsimm-inf-The inflammasome and alum-mediated adjuvanticityimm-inf-The role of microbial polysaccharides in host-pathogen interactionimm-inf-Thymic egress- S1P of 1000imm-inf-Two mechanisms that account for major histocompatibility complex restriction of T cellsimm-inf-Why is Pseudomonas aeruginosa a pathogenimm-The role of IL-23 in the immunopathogenesis of psoriasisns-A current view of Alzheimer's diseasens-An uncorrelated state for the cortexns-channelopathies- new antibody-mediated disorders of the central nervous systemns-Control of Schwann cell myelinationns-De novo prionsns-Development of object recognition in humansns-Dysfunction of the CaV2.1 calcium channel in cerebellar ataxiasns-E3 ubiquitin ligases in neurogenesisns-mechanotransduction in inner-ear hair cellsns-Multiple functions of dopamine neuronsns-Music drives brain plasticityns-Neuronal calcium sensor proteinsns-Recent advances in neural developmentns-Seeing with the mind's eyens-Setting the absolute threshold of visionns-Sources of the spatial code within the hippocampusns-The growth cone- an integrator of unique cues into refined axon guidancens-The posterior parietal cortex and non-spatial cognitionns-Transcranial magnetic stimulation studies of visuospatial attentional controlns-What drives corticospinal outputns-Why do oligodendrocyte lineage cells express glutamate receptorsphysiol-'Functional' body composition- differentiating between benign and non-benign obesityphysiol-Biased agonismphysiol-Bitopic ligands- all-in-one orthosteric and allostericphysiol-Central control of feedingphysiol-Depression and metabolism- linking changes in leptin and ghrelin to moodphysiol-Malarial parasite pathogenesis and drug targetsphysiol-Multiple functions of dopamine neuronsphysiol-New antibiotics for antibiotic-resistant bacteriaphysiol-pharmacol-The pathophysiology of diastolic heart failurephysiol-Purinergic cotransmissionphysiol-Regulation of the mTOR signaling pathwayphysiol-Role of neuropeptides, hormones, and growth factors in regulating thymopoiesis in middle to old age physiol-Stress and eating behaviourphysiol-Targeting cytokines in inflammatory diseasesphysiol-The ABCB1 transporter gene and antidepressant responsephysiol-The evolving story of orexin biology- the hits keep comingphysiol-TRPV4 as a target for bladder overactivityphysiol-Using the ribosome to synthesize peptidomimeticsstructural biology-Biased agonismstructural biology-Describing protein conformational ensemblesstructural biology-Detailed mechanism for transposition by TnpA transposase involves DNA -shape rather than direct protein-DNA recognition to generate an active nucleoprotein complexstructural biology-Diversity of protein structures and difficulties in fold recognition-the curious case 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domainsstructural biology-Unnatural amino acids- better than the real thingsF1000 Top 10bi-A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injurybi-Cell line misidentification- the beginning of the endbi-Chaperonin-dependent accelerated substitution rates in prokaryotesbi-Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse modelbi-Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsisbi-High-resolution analysis of parent-of-origin allelic expression in the mouse brainbi-Long-timescale molecular-dynamics simulations of the major urinary protein provide atomistic interpretations of the unusual thermodynamics of ligand bindingbi-Mammalian microRNAs predominantly act to decrease target mRNA levelsbi-Robust Growth of Escherichia colibi-Sex-specific parent-of-origin allelic expression in the mouse brainbi-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopybi-The genetic landscape of a cellbiochem-Functional modules and structural basis of conformational coupling in mitochondrial complex I biochem-In Vivo Double and Triple Labeling of Proteins Using Synthetic Amino Acidsbiochem-One SNARE complex is sufficient for membrane fusionbiochem-Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopybiochem-Robust Growth of Escherichia colibiochem-Self-confirming AND logic nanoparticles for fault-free MRIbiochem-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopybiochem-Structure of RCC1 chromatin factor bound to the nucleosome core particlebiochem-Structure of the torque ring of the flagellar motor and the molecular basis for rotational switching biochem-The architecture of respiratory complex Ibiochem-The functional capacity of the natural amino acids for molecular recognitionbiochem-Widespread Protein Aggregation as an Inherent Part of Aging in C. elegansbiology-Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestinebiology-An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosisbiology-Astrocytes control breathing through pH-dependent release of ATPbiology-Chaperonin-dependent accelerated substitution rates in prokaryotesbiology-Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickelbiology-Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertensionbiology-MiR-33 contributes to the regulation of cholesterol homeostasisbiology-Neuroscience and the correct level of explanation for understanding mindbiology-Role of secondary sensory cortices in emotional memory storage and retrieval in ratsbiology-Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancerbiology-TGF-beta signaling specifies axons during brain developmentbiology-The Amphimedon 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Discovery of two lead series with high ligand efficiency biotech-Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsisbiotech-Metabolomic and transcriptomic stress response of Escherichia colibiotech-Sex-specific parent-of-origin allelic expression in the mouse brainbiotech-Small-molecule inducers of insulin expression in pancreatic {alpha}-cellsbiotech-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopybiotech-The genetic landscape of a cellbiotech-Type IIA topoisomerase inhibition by a new class of antibacterial agentsca-A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distributionca-Allogeneic hematopoietic cell transplantation for hematological malignancyca-An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma proteinca-Cdc14- a highly conserved family of phosphatases with non-conserved functionsca-Early 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phosphorylation of PPARgamma by Cdk5cv-Cardiovascular and cancer mortality in very elderly post-myocardial infarction patients receiving statin treatment.-cv-Cardiovascular and cancer mortality in very elderly post-myocardial infarction patients receiving statin treatmentcv-Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronarysyndromes (PLATO)-a randomised double-blind studycv-Comparison of weight-loss diets with different compositions of fat, protein, and carbohydratescv-Dabigatran versus warfarin in patients with atrial fibrillationcv-Directed transdifferentiation of mouse mesoderm to heart tissue by defined factorscv-Effect of calcium supplements on risk of myocardial infarction and cardiovascular events-cv-Effect of calcium supplements on risk of myocardial infarction and cardiovascular eventscv-Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetescv-Effects of intensive blood-pressure control in type 2 diabetes mellituscv-Enalapril in infants with single ventricle- results of a multicenter randomized trialcv-Feedback amplification of fibrosis through matrix stiffening and COX-2 suppressioncv-Identification of a Kir3.4 mutation in congenital long QT syndrome-cv-Identification of a Kir3.4 mutation in congenital long QT syndromecv-Impact of lipid-lowering therapy on outcomes in atrial fibrillationcv-Inhibiting mitochondrial fission protects the heart against ischemia-reperfusion injurycv-Involvement of reductive stress in the cardiomyopathy in transgenic mice with cardiac-specific overexpression of heat shock protein 27cv-Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferationcv-Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism-cv-Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanismcv-Maintenance of sinus rhythm and survival in patients with heart failure and atrial fibrillationcv-Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5cv-MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis cv-Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndromecv-Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytescv-Renal and retinal effects of enalapril and losartan in type 1 diabetescv-Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trialcv-Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndromecv-Stenting versus endarterectomy for treatment of carotid-artery stenosiscv-Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflexcv-Telemonitoring and self-management in the control of hypertension (TASMINH2)cv-Telmisartan, ramipril, or both in patients at high risk for vascular eventsecology-A global network of coexisting microbes from environmental and whole-genome sequence data ecology-Competition limits adaptation and productivity in a photosynthetic alga at elevated CO2ecology-Ecosystem response to elevated CO(2) levels limited by nitrogen-induced plant species shiftecology-Local adaptation and the evolution of species' ranges under climate changeecology-Parasite prevalence and the worldwide distribution of cognitive abilityecology-Promiscuity and the evolutionary transition to complex societiesecology-Statistical inference for noisy nonlinear ecological dynamic systemsecology-The quantitative genetics of phenotypic robustnessgenome-cell line misidentificationgenome-Chaperonin-dependent accelerated substitution rates in prokaryotesgenome-Chromosome size differences may affect meiosis and genome sizegenome-Common SNPs explain a large proportion of the heritability for human heightgenome-Dissecting cancer through mathematics- from the cell to the animal modelgenome-Global analysis of trans-splicing in Drosophilagenome-High-resolution analysis of parent-of-origin allelic expression in the mouse braingenome-Inaugural Article- Fast live simultaneous multiwavelength four-dimensional optical microscopy genome-Segregation of yeast nuclear poresgenome-Statistical design and analysis of RNA sequencing datagenome-The coevolution of human hands and feetgenome-The genetic landscape of a cellgenome-Trans-acting small RNA determines dominance relationships in Brassica self-incompatibilityimm-A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosisimm-Activation of a metabolic gene regulatory network downstream of mTOR complex 1imm-An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosisimm-Duration of antibiotic therapy in hospitalised patients with community-acquired pneumoniaimm-Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapseimm-Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infectionimm-Evidence of dysregulation of dendritic cells in primary HIV infectionimm-Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearanceimm-Glutamine uptake and metabolism are coordinately regulated by ERK-MAPK during T lymphocyte activation imm-IgT, a primitive immunoglobulin class specialized in mucosal immunityimm-Immature Dengue Virusimm-Lipid accumulation and dendritic cell dysfunction in cancerimm-Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognitionimm-Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppressionimm-Novel Treponema pallidum Serologic Testsimm-Patient safety culture- factors that influence clinician involvement in patient safety behavioursimm-Persistent activation of an innate immune response translates respiratory viral infection into chronic lung diseaseimm-Prolonged infectiousness of tuberculosis patients in a directly observed therapy short-course program with standardized therapyimm-Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1imm-Single-cell NF-kappaB dynamics reveal digital activation and analogue information processingimm-Standard versus newer antibacterial agents in the treatment of severe acute exacerbation of chronic obstructive pulmonary diseaseimm-Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01imm-The latest threat in the war on antimicrobial resistanceimm-Transgenic mice with a diverse human T cell antigen receptor repertoiremol biol-A split active site couples cap recognition by Dcp2 to activation。