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诺禾致源2014产品手册

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CONTENTS
建库测序
06 建库测序服务
基因组测序
08 动植物基因组测序 10 基因组特征评估 11 基因组de novo测序 14 泛基因组测序(pan-genome) 16 动植物重测序 17 变异检测(基于全基因组重测序) 19 变异检测(基于简化基因组测序) 21 单个性状定位 24 遗传图谱(基于全基因组重测序) 26 遗传图谱(基于简化基因组测序) 28 群体进化(基于全基因组重测序) 30 群体进化(基于简化基因组测序)
[2] Zhi X Y, Yao J C, Li H W, et al. Genome-wide identification, domain architectures and phylogenetic analysis provide new insights into the early evolution of shikimate pathway in prokaryotes[J]. Molecular phylogenetics and evolution, 2014, 75: 154-164.
[8] Xu X, Dong G X, Hu X S, et al. The genetic basis of white tigers[J]. Current Biology, 2013, 23(11): 1031-1035. [9] Jiang W, Liu Y, Xia E, et al. Prevalent role of gene features in determining evolutionary fates of whole-genome duplication duplicated genes in flowering plants[J]. Plant physiology, 2013, 161(4): 1844-1861. [10] Zhang G, Cowled C, Shi Z, et al. Comparative analysis of bat genomes provides insight into the evolution of flight and immunity[J]. Science, 2013, 339(6118): 456-460. [11] Fan Y, Huang Z Y, Cao C C, et al. Genome of the Chinese tree shrew[J]. Nature communications, 2013, 4: 1426. [12] Wang M Y, Zhao P M, Cheng H Q, et al. The Cotton transcription factor TCP14 functions in auxin-mediated epidermal cell differentiation and elongation[J]. Plant physiology, 2013, 162(3): 1669-1680. [13] Lu S, Zong C, Fan W, et al. Probing meiotic recombination and aneuploidy of single sperm cells by wholegenome sequencing[J]. Science, 2012, 338(6114): 1627-1630. [14] Guo S, Zhang J, Sun H, et al. The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions[J]. Nature genetics, 2013, 45(1): 51-58. [15] Li S, Li R, Li H, et al. SOAPindel: Efficient identification of indels from short paired reads[J]. Genome research, 2013, 23(1): 195-200. [16] Li M, Wu H, Luo Z, et al. An atlas of DNA methylomes in porcine adipose and muscle tissues[J]. Nature communications, 2012, 3: 850. [17] Fan W, Li R. Test driving genome assemblers[J]. Nature biotechnology, 2012, 30(4): 330. [18] Liu C M, Wong T, Wu E, et al. SOAP3: ultra-fast GPU-based parallel alignment tool for short reads[J]. Bioinformatics, 2012, 28(6): 878-879. [19] Hvilsom C, Qian Y, Bataillon T, et al. Extensive X-linked adaptive evolution in central chimpanzees[J]. Proceedings of the National Academy of Sciences, 2012, 109(6): 2054-2059. [20] Zhang G, Fang X, Guo X, et al. The oyster genome reveals stress adaptation and complexity of shell formation[J]. Nature, 2012, 490(7418): 49-54.
[1] Zhi X Y, Yao J C, Tang S K, et al. The futalosine pathway played an important role in menaquinone biosynthesis during early prokaryote evolution[J]. Genome biology and evolution, 2014, 6(1): 149-160.
[4] Li M, Tian S, Jin L, et al. Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars[J]. Nature genetics, 2013, 45(12): 1431-1438.
2、计算平台 诺禾致源计算平台采用DELL计算节点和Isilon存储的高效组合,总内存大小为12.33TB,计算能力高达
22.82Tflops,高性能储存容量2.3PB。随着公司的发展,计算平台还将不断扩容,以保证高效的数据处理和安 全的数据存储。
DELL大型服务器:用于数据处理及存储
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团队成员发表文章
目录
转录调控测序
32 mRNA测序 33 真核mRNA测序 34 真核Single cell转录组测序 36 比较转录组与泛转录组(pan-transcriptome)测序 38 原核转录组测序 40 非编码RNA测序 40 LncRNA测序 42 Single cell LncRNA测序 44 Small RNA测序 46 表观遗传测序 46 全基因组甲基化测序 48 ChIP-seq 50 多组学关联分析
微物
52 细菌基因组测序 55 真菌基因组测序 58 小基因组测序 60 16S/18S/ITS等扩增子测序 63 宏基因组测序
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诺禾致源 北京诺禾致源生物信息科技有限公司于2011年3月15日在北京中关村生命科学 园注册成立,以基因组学研究与应用开发为发展方向,致力于成为全球领先的基因组学研究解决方案提供者。专 注于开拓生物学、计算机科学和信息技术在动植物研究以及人类健康领域的应用。
诺禾致源总部位于北京市海淀区学清路金码大厦B座17、21层,总办公面积4500平米。天津分公司位于天津 市武清区创业总部基地B07与B08栋,办公面积5600平米,其中实验室面积2000平米。为国家高新技术企业、双 软企业、北京市科技研究开发机构、北京市博士后流动站、北京市企事业专利试点单位。
诺禾致源拥有全球领先的高通量测序平台,包括4台HiSeq2000、6台HiSeq2500、4台MiSeq,并且搭建 了国内首个NextSeq 500、HiSeq X Ten 测序平台。诺禾致源高性能计算平台(HPC)采用了DELL计算节点和 Isilon存储的高效组合,拥有2.3PB的存储资源,高达22.82Tflops的计算能力;总内存大小为12.33TB,能有效支 撑生命科学研究、农业育种、食品安全和医疗健康等领域对数据分析的需求。
[3] Cao S, Han J, Wu J, et al. Specific gene-regulation networks during the pre-implantation development of the pig embryo as revealed by deep sequencing[J]. BMC genomics, 2014, 15(1): 4.
[6] Li Y, Zhao S, Ma J, et al. Molecular footprints of domestication and improvement in soybean revealed by whole genome re-sequencing[J]. BMC genomics, 2013, 14(1).
[7] Qu Y, Zhao H, Han N, et al. Ground tit genome reveals avian adaptation to living at high altitudes in the Tibetan plateau[J]. Nature communications, 2013, 4.
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