Cancer Nanotech——NCI 2004
Fe3O4 Fe3O4
丰富多彩的纳米材料
Fe2O3/SiO2
核 壳
结
构
磁
性
荧
光
纳
米
棒
Au
Au Fe2O3/CdTe/Alg
Fe3O4/PLA
Au
CdTe QDs
TiO2
Angew. Chem. Int. Ed. 2007；Nanoscale Res Lett. 2009; J. Phys. Chem. C 2010； Journal of Controlled Release 2008；Materials Letters 2008；Biomaterials 2009；Small, 2010；J Mater
——NCI 2004
Imaging Diagnostics •Designing “smart” injectable, targeted contrast agents that improve the resolution of cancer to the single cell level •Engineering nanoscale devices capable of addressing the biological and evolutionary diversity of the multiple cancer cells that make up a tumor within an individual
Nano-Clinics
Cancer Nanotech——NCI 2004
学科交叉 医工结合 转化医学
Quality of Life Enhancement in Cancer Care • Designing nanoscale devices that can optimally deliver medications for treating conditions that may arise over time with chronic anticancer therapy, including pain, nausea, loss of appetite, depression, and difficulty breathing Interdisciplinary Training •Coordinating efforts to provide cross-training in molecular and systems biology to nanotechnology engineers and in nanotechnology to cancer researchers •Creating new interdisciplinary coursework/degree programs to train a new generation of researchers skilled in both cancer biology and nanotechnology
生物医学纳米技术
张宇 zhangyu@ 生物科学与医学工程学院
《生物医学纳米技术》
第四讲：纳米颗粒与肿瘤诊治
物质尺度
纳米效应
1纳米（nm）=10-9米（m） 1纳米（nm）=10 埃（A）
用特殊尺度空间的物质来改变人们的认识！
纳米生物医学
——纳米技术与生物医学的交叉与融合。 ——同时，纳米生物学、纳米医学又是纳米科学与技术的重要研究领域。
Early Detection and Proteomics •Creating implantable, biofouling-indifferent molecular sensors that can detect cancerassociated biomarkers that can be collected for ex vivo analysis or analyzed in situ, with the results being transmitted via wireless technology to the physician •Developing “smart” collection platforms for simultaneous mass spectroscopic analysis of multiple cancer-associated markers
纳生米物 Nhomakorabea技
医
术
学
纳米生物医学
肿瘤：诊断与治疗，能否象慢性病一样控制？
Prevention and Control of Cancer •Developing nanoscale devices that can deliver cancer prevention agents •Designing multicomponent anticancer vaccines using nanoscale delivery vehicles
Multifunctional Therapeutics •Developing nanoscale devices that integrate diagnostic and therapeutic functions •Creating “smart” therapeutic devices that can control the spatial and temporal release of therapeutic agents while monitoring the effectiveness of these agents
纳米生物学医学：
一方面，是利用纳米技术（包括纳米材料）研究生命体的特征，发现新 的生命现象和规律，为人类健康和疾病诊断与治疗提供新的理论和方 法；
另一方面，模拟生命体精细的调节机制，通过仿生研究制备新型纳米材 料和建立新的纳米技术。
纳米物理学 纳米化学 纳米材料学 纳米 纳米加工学 科学 纳米测量学 技术 纳米机械学 纳米电子学 纳米生物学 纳米医学