• The turnover of pathogenetic condition relate with autoimmune response intensity
• Recurrent attacks and chronic
三、Classification
• Organ-specific autoimmune disease
六、Biotherapy
• Antibody • Vaccine
Pharmaceutical Biotechnology 2012, 19( 4) : 364 ～ 368. ChineseJournalofNewDrugs2011, 20(8)
How to better solve the suffering of patients
New ways
七、Gene and Cell therapy
• DC、NK、CIK、B、T、LAK • Stem cells(HSC、MSC…….）
八、Stem Cell therapy for AID
• 1.Definition & Historic landmarks • 2.Cell types: MSC origin and • 3.Cell harvest, culture and store • 4.Delivery method • parative Evaluation • 6.Animal experimental • 7.Mechanism • 8. Clinical experimental • 9.Conclusion
常见自身免疫病
类别 非器官特异性
器官特异性
病名
系统性红斑狼疮 类风湿性关节炎 干ves病 Addison病 幼年型糖尿病 萎缩性胃炎 溃疡性结肠炎 原发性胆汁性肝硬化 重症肌无力 自身免疫性溶血性贫血 特发性血小板减少性紫癜
自身抗原
胞核成分（DNA,DNP,RNP,Sm） 变性IgG,类风湿相关的核抗原 细胞核（SS-A,SS-B）,唾液腺管 胞浆线粒体,微粒体,红细胞,血小板 细胞核（RNP）
liver Cartilage Synovium Dental pulp Tonsil PlacentaUmbilical Cord Thymus PericytesAmniotic fluid
/library/images/in-vivo-mesenchymal-stem-cells-origin César Nombela-Arrieta,Nature Reviews Molecular Cell Biology 12, 126-131 (2011)
甲状腺球蛋白、微粒体 甲状腺细胞表面THS受体 肾上腺皮质细胞 胰岛细胞 胃壁细胞 结肠上皮细胞 胆小管细胞、线粒体 乙酰胆碱受体 红细胞 血小板
五、Traditional therapy
• General therapy • Cortisone • Immune inhibitors • Others
UB-MSC: the new gold standard to treat several human diseases, especially autoimmune diseases
Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine
Junming Tang 2015.8
Outline
• 一、Definition • 二、Characteristics • 三、Classification • 四、Pathogenesis • 五、Traditional therapy • 六、Biotherapy(antibody、vaccine、gene
二、Characteristics
• Autoimmune antibody and (or) autoreactive T lymphocyte can be detected.
• Autoimmune antibody and (or) autoreactive T lymphocyte mediate immune response which lead to damage or functional disturbance
therapy ) • 七、Cell therapy(DC、HSC、MSC)
一、Definition
• Autoimmunity refer to the immune responses to self cells or self components.
• Autoimmune disease refer to the disease state resulted from immune responses directed against self cells or self components.
system(autoreactive T lymphocyte) • Genetics and endocrine
Examples of Human Autoimmune Diseases with Possible Molecular Mimicry as a Mechanism
Clin Rev Allergy Immunol. 2012; 42(1): 102¤C11
Graves‘ disease、insulin-dependent diabetes mellitus
• Systemic autoimmune disease systemic lupus erythematosus
四、Pathogenesis
• Autoimmune antibody • Disfunction immunologic
1.Stem cells
Historic landmarks in the field of stem cell biology
15
Circ Res. 2014;114:21-27.)
2.Cell types
16
MSC: origin and biological traits
Bone marrow Kidney Pancreas Adipose tissue Muscle Brain