Clinical manifestations
1. Tuberculosis toxic symptoms
Low fever, night sweats, anorexia, weight loss,and fatigue
2. Lung clinical manifestatios：
Symptoms is mild:dry cough Signs are not obvious generally (signs in lung is not
Basic lesions ： exudative lesions: epithelioid cells, lymphocytes, and fibroblasts proliferative lesions: tubercle, tuberculous granuloma caseous necrosis
Lymphogenic spread lymphangitis
Hilar lymph nodes lymphadenitis
Primary complex
PAM: pulmonary alveolar macrophages
Primary focus Lymphangitis Lymphadenitis
2. Clinical manifestations ：
Tuberculosis toxic symptoms Respiratory symptoms Manifestations of tuberculosis hypersensitivity
Pathogenesis
Droplet nuclei inhalation
alveoli Intracellular replication
of bacilli
destruction of PAM’S
Ingestion by PAM’S Destruction of bacilli
Tubercle formation Primary focus
Prognosis of primary palmonary tuberculosis:
Primary complex
Healing with
obsorption calcification scleroma
Deterioration :Hematogenic
spread
Progression
probof pediatric TB
1. More severe tuberculosis infection 2. Tissues and organs are hypersensitivity to
tuberculosis bacili 3. Lymphatic system involved widely 4. Systemic spread tendency
Primary pulmonary tuberculosis
Primary pulmonary TB is a tuberculosis that is caused by primary pulmonary infection of M. tuberculosis.
Primary pulmonary TB includes: Primary complex Tuberculosis of trachebronchial lymphnodes
5. the location of primary focus in lungs is special 6. prognosis is good in most children with primary
tuberculosis and lesion is healed with absorption, calcification or scleroma 7. Most of them have contact history with tuberculosis patients 8. The smaller the age, the bigger the PPD-test value
Expansion of lesions
Diagnosis
1. Epidemiology history ：
History of contact with tuberculosis person BCG vaccination history History of infectious diseases recently
Tuberculosis in children
EPIDEMIOLOGY - TB
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis.
TB has affected human for a long time. Now, TB remains a leading public health
－
typical
atypical
Tuberculosis of
primary complex
trachebronchial lymphnodes
Primary palmonary tuberculosis
Pathology
Location of primary focus : low zones of lobus superior pulmonis or upper zone of lobus inferior pulmonis subpleural right lung mostly
consistent with the lesions in lung lesions not consistent)
Clinical manifestations
3. Oppression symptoms of Bronchial lymph node 4. Extrapulmonary clinical manifestations： 5. others：