showed massive changes throughout the lobules, with fatty accumulations, cellular vacuolization, and necrosis, as well as dilation of Disse spaces with focal disruption of the sinusoidal endothelium, inflammatory infiltrations of the portal triads, and distortion of the central venules.
<2013-FCT-Hepatoprotective and antioxidant activity of aqueous extract of Hybanthus enneaspermus against CCl4-induced liver injury in rats>
(B) animals treated with 50% CCl4 (2 mL/kg of bw) showed severe fatty degeneration (big arrow), cell necrosis (arrow) and vacuole formation (small arrowhead)
《2007-FCT-Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats》
(B) Liver section of CCl4-treated mice (group II), showing marked hepatocellular necrosis, massive fatty changes and extensive vacoulisation with disappearance of nuclei as well as broad infiltration of the lymphocytes and prominent and enlarged cen tral vein, respectively
<2009-FCT-Protective effect of Cichorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice>
(C) Animals treated with CCl4 only exhibited severe confluent, inflammatory cell infiltration and ballooning changes (arrow)
<2011-JAFC-Hepatoprotective Effects of 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone on CCl4-Induced Acute Liver Injury in Mice>
Magnification: 200x 1.degeneration 2. vacuole 3. necrosis 4. eosinophil infiltration.。