only when eating.
✓1920 and 1930 an increasing number of
patients: abdominal cramping, diarrhea,
fever and weight loss that turned out not to
be appendicitis.
Professor of Medicine. Dr. Sands is an expert in
the management of inflammatory bowel diseases
(IBD) and has earned an international reputation
froerfrhaicstocrayrediosfeapsaeti.ents首w批ith报co道mplIenxfalned ximab治疗UC有效的医
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5
Crohn's disease
克罗恩医生(June 13, 1884 in
New York – July 29, 1983 in
Connecticut) was an American
gastroenterologist and one of
the first to describe the
discomfort and much embarrassment (diarrhea)
whenever he ate.
✓In 1612 an autopsy was performed on a young buol一cye类wrah新ot'e的sd疾ainn病dte表wsht现oimn为ehs：adw腹ecr部oem绞pnlo痛atie、nde发dto热prb和ieo体r 重to下 hi降s；de但at不h是of阑p尾ai炎n and abdominal cramping
disease for which he is
iknno1w9n3,0 CDrro.hnC'rsohdnispeuabslei.shed a paper in c“ol末la端bo回ra肠ti炎on：w一it种h 新th的e 临ot床he疾rs病i存nc在lu形di式ng Dr.
Paul Klemperer on a medical condition they
most Unit
raescew组netlll织yassAeCrAvsCesdoEcNaisaTttehIePIrhoofsespstistouardl'oysf的AMcetd主iincgi要nCeh研iaetf究Hoafr者vtahredΒιβλιοθήκη Medical School.
A longtime advocate for the continued translational research in CD and UC,
call “Terminal Ileitis: A new clinical
entity” later to be called Crohns Disease. Mount Sinai Hospital
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6
Crohn's disease
IBD转化医学专家
Bruce Sands, MD, MS is the Dr. Burrill B. Crohn
✓日本现有IBD10万人，其中UC8万，CD2万
✓我国UC与CD的患病率分别: 11.6/10万和1.4/10万
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4
Crohn's disease
✓850 AD. Written documentation of England‘s King Alfred : an illness causing pain,
生 He joined Mount Sinai in 2010 as Chief of the Henry D. Janowitz Division of
GI. … was Medical Co-Director of the Crohn's & Colitis Center at MGH in
Boston, where he Gastrointestinal
疾病，并称之为“单纯性特发性结肠炎”
✓美国外科军医在南北战争的医史记录中亦有采用 “UC” 病名，描述并了本病的病理组织学微观变
化
✓Allchinz在1885年，以及Hale和White在1888年逐 步将UC的临床病理特征进行了比较详细的描述
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3
溃疡性结肠炎的沿革
✓1909 年Hawkin 进一步报道了这种结肠炎病例，并 指出其慢性复发性的特点
among the first to report the efficacy of infliximab-a drug used to treat
autoimmune diseases-in UC, … principal investigator for the landmark ACCENT
II study, an international project that demonstrated the MeofufnitcaSciynoafi tHhoesp.i.tal
炎症性肠病
--
1
IBD研究的历史沿革
--
2
溃疡性结肠炎的沿革
✓Arestaeus(A.D.300)和Soranus(A.D.117) “非传 染性腹泻”
✓1859 年由英国伦敦Guy 医院的Samuel Wilks 医 生使用首次溃疡性结肠炎（ulcerative colitis）
之病名，认为是一种有别于细菌性痢疾的独立性
infliximab as a long-term treatment for--fistulizing CD.
7
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8
cobblestone
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9
中华医学会消化病学分会共识
中华医学会5次制定我国IBD的诊治规范建议：
✓同年，伦敦皇家医学会报道了从伦敦各家医院收集 的300 例以上的UC病例，并开展了相关的病因讨论。
以后，UC开始在欧美各国，尤其是白种人中陆续被
报道……
✓欧洲和北美的UC发病率为10-20/105、患病率达 100～200／105，而克罗恩病（CD）的发病率为5～
10／105、患病率为50～100/105