SIGMA-ALDRICH Material Safety Data SheetVersion 4.0Revision Date 07/29/2010Print Date 03/21/20111. PRODUCT AND COMPANY IDENTIFICATIONProduct name : Isophorone diisocyanateProduct Number : 317624AldrichBrand :Sigma-AldrichCompany :3050 Spruce StreetSAINT LOUIS MO 63103USA+18003255832Telephone :+18003255052Fax :Emergency Phone # : (314) 776-65552. HAZARDS IDENTIFICATIONEmergency OverviewOSHA HazardsHighly toxic by inhalation, Respiratory sensitiser, IrritantOther hazards which do not result in classificationLachrymator.GHS Label elements, including precautionary statementsPictogramSignal word DangerHazard statement(s)H303 May be harmful if swallowed.H315 Causes skin irritation.H319 Causes serious eye irritation.H330 Fatal if inhaled.H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.H335 May cause respiratory irritation.H401 Toxic to aquatic life.Precautionary statement(s)P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.P284 Wear respiratory protection.P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, ifpresent and easy to do. Continue rinsing.P310 Immediately call a POISON CENTER or doctor/ physician.HMIS ClassificationHealth hazard:3Chronic Health Hazard:*Flammability:1Physical hazards:0NFPA RatingHealth hazard:4Fire:1Reactivity Hazard:0Potential Health EffectsInhalation May be fatal if inhaled. Causes respiratory tract irritation.Skin May be harmful if absorbed through skin. Causes skin irritation.Eyes Causes eye irritation.Ingestion May be harmful if swallowed.3. COMPOSITION/INFORMATION ON INGREDIENTS5-Isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane Synonyms :C12H18N2O2Formula :Molecular Weight : 222.28 g/molCAS-No. EC-No.Index-No. ConcentrationIsophorone di-isocyanate- 4098-71-9 223-861-6615-008-00-54. FIRST AID MEASURESGeneral adviceConsult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.If inhaledIf breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician.In case of skin contactWash off with soap and plenty of water. Consult a physician.In case of eye contactRinse thoroughly with plenty of water for at least 15 minutes and consult a physician.If swallowedNever give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.5. FIRE-FIGHTING MEASURESSuitable extinguishing mediaUse water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Special protective equipment for fire-fightersWear self contained breathing apparatus for fire fighting if necessary.6. ACCIDENTAL RELEASE MEASURESPersonal precautionsWear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Environmental precautionsPrevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Methods and materials for containment and cleaning upSoak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.7. HANDLING AND STORAGEPrecautions for safe handlingAvoid contact with skin and eyes. Avoid inhalation of vapour or mist.Normal measures for preventive fire protection.Conditions for safe storageKeep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Moisture sensitive.8. EXPOSURE CONTROLS/PERSONAL PROTECTIONComponents with workplace control parametersComponents CAS-No. Value ControlparametersUpdate BasisIsophorone di-isocyanate 4098-71-9 TWA0.005 ppm2007-01-01 USA. ACGIH Threshold Limit Values(TLV)Remarks RespiratorysensitizationTWA0.005 ppm1989-01-19 USA. OSHA - TABLE Z-1 Limits for AirContaminants - 1910.1000 SkinnotationSTEL0.02 ppm1989-01-19 USA. OSHA - TABLE Z-1 Limits for AirContaminants - 1910.1000 SkinnotationPersonal protective equipmentRespiratory protectionWhere risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If therespirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).Hand protectionHandle with gloves.Eye protectionFace shield and safety glassesSkin and body protectionChoose body protection according to the amount and concentration of the dangerous substance at the work place.Hygiene measuresAvoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.9. PHYSICAL AND CHEMICAL PROPERTIESAppearanceForm liquidSafety datapH no data availableMelting point no data availableBoiling point 158 - 159 °C (316 - 318 °F) at 20 hPa (15 mmHg) - lit.Flash point 163 °C (325 °F) - closed cupIgnition temperature no data availableLower explosion limit no data availableUpper explosion limit no data availableDensity 1.049 g/cm3 at 25 °C (77 °F)Water solubility no data available10. STABILITY AND REACTIVITYChemical stabilityStable under recommended storage conditions.Conditions to avoidAvoid moisture.Materials to avoidStrong oxidizing agents, Strong acids, AlcoholsHazardous decomposition productsHazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx)11. TOXICOLOGICAL INFORMATIONAcute toxicityLD50Oral - rat - 4,825 mg/kgLC50Inhalation - rat - 4 h - 123 mg/m3Skin corrosion/irritationno data availableSerious eye damage/eye irritationno data availableRespiratory or skin sensitizationMay cause allergic respiratory reaction.Germ cell mutagenicityno data availableCarcinogenicityIARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as acarcinogen or potential carcinogen by ACGIH.NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as acarcinogen or potential carcinogen by OSHA.Reproductive toxicityno data availableSpecific target organ toxicity - single exposure (Globally Harmonized System)May cause respiratory irritation.Specific target organ toxicity - repeated exposure (Globally Harmonized System)no data availableAspiration hazardno data availablePotential health effectsInhalation May be fatal if inhaled. Causes respiratory tract irritation.Ingestion May be harmful if swallowed.Skin May be harmful if absorbed through skin. Causes skin irritation.Eyes Causes eye irritation.Signs and Symptoms of ExposureMaterial is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, NauseaAdditional InformationRTECS: NQ937000012. ECOLOGICAL INFORMATIONToxicityno data availablePersistence and degradabilityno data availableBioaccumulative potentialno data availableMobility in soilno data availablePBT and vPvB assessmentno data availableOther adverse effectsAn environmental hazard cannot be excluded in the event of unprofessional handling or disposal.Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.13. DISPOSAL CONSIDERATIONSProductObserve all federal, state, and local environmental regulations. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.Contaminated packagingDispose of as unused product.14. TRANSPORT INFORMATIONDOT (US)UN-Number:2290 Class: 6.1 Packing group: IIIProper shipping name: Isophorone diisocyanateMarine pollutant: NoPoison Inhalation Hazard: NoIMDGUN-Number: 2290 Class: 6.1 Packing group: III EMS-No: F-A, S-AProper shipping name: ISOPHORONE DIISOCYANATEMarine pollutant: NoIATAUN-Number:2290 Class: 6.1 Packing group: IIIProper shipping name: Isophorone diisocyanate15. REGULATORY INFORMATIONOSHA HazardsHighly toxic by inhalation, Respiratory sensitiser, IrritantDSL StatusAll components of this product are on the Canadian DSL list.SARA 302 ComponentsIsophorone di-isocyanate CAS-No.4098-71-9Revision Date2007-07-01SARA 313 ComponentsSARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312HazardsAcute Health HazardMassachusetts Right To Know ComponentsIsophorone di-isocyanate CAS-No.4098-71-9Revision Date2007-07-01Pennsylvania Right To Know ComponentsIsophorone di-isocyanate CAS-No.4098-71-9Revision Date2007-07-01New Jersey Right To Know ComponentsIsophorone di-isocyanate CAS-No.4098-71-9Revision Date2007-07-01California Prop. 65 ComponentsThis product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.16. OTHER INFORMATIONFurther informationCopyright 2010 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.。