For the flow phantom studies, either the
concentration of MB
contrast agent was held
constant (10 μL/L) with varying volumetric flow
rates (10, 20, and 30 mL/min) or the flow rate was
通过鉴别缺血组织区域，肾脏造影能够对由于肾脏并发症造成的缺血组织的实际百 分比提供更加细s paper is to investigate the repeatability and robustness of VCEUS imaging for tracking perfusion changes in the healthy and injured kidney.
这篇文章主要致力于观察超声造影显像追踪正常及受损肾脏灌注变化的可重复性及 稳定性。
二Method
VCEUS utilizes a series of planar image acquisitions, capturing the non-linear second harmonic signal from microbubble (MB) contrast agents flowing in the vasculature. Tissue perfusion parameters (peak intensity, IPK; time-to-peak intensity, TPK; wash-in rate, WIR; area
Volumetric contrast-enhanced ultrasound imaging of renal
perfusion
肾灌注的容积超声造影显像
一 Objective
Volumetric contrast-enhanced ultrasound (VCEUS) imaging has the potential to monitor changes in renal perfusion following vascular injury.
μL/L).
Animal studies were performed using either healthy rats or those that underwent renal ischemiareperfusion injury. A series of renal studies were performed using healthy rats (N = 4) while the angle of the transducer was varied for each VCEUS image acquisition (reference or 0°, 4动脏5物研°研究,究，a应每n用次d健超9康声0小造°鼠影)及图t遭像o受采a缺集s血的se再传s灌感s注器i的角f 小度re鼠是p来多e完变at成的e。（d用参r正考en常角a小度l鼠为p完0e°、成rf4一5u°系、s列i9o0肾°n m）e，a以s便ur评e估s重w复e的r肾e脏is灌o注tr方o法p是ic等a向n性d的，in其d独e立pe于n传d感e器n方t 位o。f 血浆生物标 tr记a物n及sd免u疫c组e织r 学p用os来i确ti诊o急n.性B肾损lo害o。d serum
在h体e外ld流速模型研究co中n，s保ta证n微t气(泡30浓度m稳L定/（m10inμL)/La）n，d改t变h容e积c流o速nt率r（as10t,
20, and 30 mL/min），或者保证流速稳定（30 mL/min），改变微气泡浓度(5, 10,
anadg20eμnLt/Lc)。oncentration was varied (5, 10, and 20
VCEUS could provide a more detailed idea of the actual percentage of ischemic tissue resulting from this renal complication by identifying regions of ischemic tissue.
• 容积超声造影显像可以作为一种监测血管损伤后肾脏灌注变化的潜在手段。
Current methods for quantifying AKI are searching for bio-markers indicative of kidney injury such as positive fluctuations in serum creatinine .However, serum creatinine levels lack the sensitivity and specificity necessary for early detection . Due to the n目e前p确h诊rAoKtIo的x方ic法主n要at通u过re寻找of血液b中o肾th脏损C害T的a生n物d标M志物R，例c如o血n肌tr酐a水st平升 a高，g。而e但其n是他ts血标,肌 准o酐灌th缺注e乏显r早像s期模ta诊式n断不d的适a敏合rd感诊p性断e及及r特监fu异测s性AiKo。I。n由于imCTa及gMiRn造g影m本o身d存a在l肾it毒ie性s are not suitable for diagnosis and monitoring of AKI.
容积超声造影通过一系列的二维图像采集，捕捉流入脉管系统的微气泡造影剂形成
u的n非d线e性r 二cu次r谐v波e信, 号A。U在C体)外w流速er模e型d及e体ri内v正e常d/受fr损o肾m脏t的im动物e研- 究中，收
集来自时间-强度曲线的组织灌注参数（峰强度、达峰值强度时间、內洗率、曲线
i下n面te积n）si。ty curve data collected during in vitro flow phantom studies and in vivo animal studies of healthy and injured kidney.