[ 3 ] Arima S, Kohagura K, Xu HL, et al. Endothelium-derived nitric oxide modulates vascular action of aldosterone in renal arteriole[ J] . Hypertension, 2004, 43 ( 2) : 352-357 .
[ 9 ] de Zeeuw D, Remuzzi G, Parving HH, et al. Proteinuria, a target for
[ 10] [ 11]
[ 12] [ 13] [ 14] [ 15] [ 16] [ 17]
renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL[ J] . Kidney Int, 2004, 65( 6) : 2309-2320. Ruggenenti P, Fassi A, Ilieva AP, et al. Bergamo nephrologic diabetes complications trial ( BENEDICT ) investigators preventing microalbuminuria in type 2 diabetes [ J] . N Engl J Med, 2004, 351 ( 19) : 1941-1951. Patel A, ADVANCE Collaborative Group, Macmahon S, et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus( the ADVANCE trial) : a randomised controlled trial [ J] . Lancet, 2007, 370( 9590) : 829-840. Huang XR, Chen WY, Truong LD, et al. Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin Ⅱ-mediated diabetic renal and vascular disease [ J] . J Am Soc Nephrol, 2003, 14( 7) : 1738-1747. Mauer M, Zinman B, Gardiner R, et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes[ J] . N Engl J Med, 2009, 361( 1) : 40-51. Bilous R, Chaturvedi N, Sj lie AK, et al. Effect of candesartan on microalbuminuria and albumin excretion rate in diabetes: three randomized trials[ J] . Ann Intern Med, 2009, 151 ( 1) : 11-20. British Cardiac Society, British Hypertension Socity, Diabetes UK, et al. JBS 2: Joint British Societies′guidelines on prevention of cardiovascular disease in clinical practice[ J] . Heart, 2005, 91( Suppl 5) : 1-52. Sato A, Hayashi K, Saruta T. Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease[ J] . Am J Hypertens, 2005 , 18( 1) : 44-49. Parving HH, Persson F, Lewis JB, et al. Aliskiren combined with
[ 4 ] Cha DR, Kang YS, Han SY, et al. Role of aldosterone in diabetic nephropathy[ J] . Nephrology( Carlton) , 2005, 10( Suppl) : S37-39.
[ 5 ] Siragy HM, Xue C. Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats[ J] . Exp Physiol, 2008, 93 ( 7) : 817-824 .
Abstract: Nuclear factor-κB( NF-κB) is a transcription factor widely distributed in most cell types with extensive biologic activity, which regulates the expression of numerous genes such as cytokine, chemotactic factor, transcriptionfactor, oxidative stress related enzymes, and acute-phase proteins etc. , accordingly participating in many bioprocesses such as inflammation responses, immunoreaction, apoptosis and stress reaction etc . . It has been found that excessive activation of NF-κB which exists in local nephridial tissue of diabetic nephropathy( DN) has a closely relationship with the proliferation of mesangial cell and the secretion of inflammatory factors. Therefore, deeper study of the relationship between NF-κB and DN contributes to the clinical prevention and therapy.
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医学 综述 2012 年 5 月第 18 卷第 9 期 Medical Recapitulate, May. 2012 , Vol. 18 , No. 9
率已经下降) 肾脏疾病的进展仍然是一个值得探讨 的问题。到目前为止仍 在进 行的 双重 RAAS 阻 断的
临床试验结果显示, 临床医师应该根据患者个人的 状况权衡 RAAS 双重 阻 断 的 益 处, 避 免有 可 能 的 不
赵建芹( 综述) , 姜兆顺※ , 穆 红, 韩晨东( 审校)
( 济南 军区总 医院 内分泌 科, 济南 250031 )
中 图分 类号: R587. 2
文献标识码: A
文章 编号: 1006-2084( 2012) 09-1388-04
摘 要: 核因子 κB( NF-κB) 是一 种广 泛存在 并具 有广 泛生 物 学活 性 的核 转 录因 子, 其 调 控的 靶 基 因包括 细胞因 子、趋化 因子 、转 录因子 、氧 化应 激相 关 酶及 急 性 期 蛋白 等 , 进 而参 与 调 控 炎症 和 免 疫 反应、细胞 生长 发育、细胞 凋亡 及应激 反应 等多种 生物过 程。 研究发 现在 糖尿病 肾 病( DN) 的局 部 肾 组织中 存在过 度激 活的 NF-κB, 其 过 度 激 活 与 肾 小 球 系膜 细 胞 增 生 和 分 泌 炎 性 因 子 密 切 相 关。 因 此, 深入研 究 NF-κB 与 DN 的 关系 , 有 助于 DN 的临 床防 治。
[ 6 ] Lee SH, Yoo TH, Nam BY, et al. Activation of local aldosterone system within podocytes is involved in apoptosis under diabetic conditions[ J] . Am J Physiol Renal Physiol, 2009, 297( 5 ) : F1381 F1390.
[ 7 ] Mauer M, Zinman B, Gardiner R, et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes[ J] . N Engl J Med, 2009 , 361( 1) : 40-51.
关 键词: 核 因子 κB; 糖尿 病; 糖尿 病肾病
常见的微血管并发症, 是糖 尿 病 患 者 的主 要 死 因 之 一。 目前 DN 的发病 机制 尚未 完 全阐明, 研究表明, 炎症机制 在 DN 的 发 生、发 展 过 程 中
Research Progress of the Correlation between Nuclear Factor -κB and Diabetic Nephropathy ZHAO Jian-qin, JIANG Zhao-shun, MU Hong, HAN Chen-dong. ( Department of Endocrinology, Jinan Military General Hospital, Jinan 250031, China)