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血清胃蛋白酶原和幽门螺杆菌抗体 联合检测预测胃癌发生风险
“正常”胃
非萎缩性胃炎
轻、中度萎缩性胃炎
重度萎缩性胃炎,广泛肠化
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39 (12–118)months
35 (12–109) months
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胃癌高发区(妈祖岛)人群干预
Bhandari A. Curr Gastroenterol Rep. 2012;14:489-96
100% 50% 40% 8% < 1%
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根除治疗
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幽门螺杆菌感染率与胃癌发病率背离的“非洲之谜”
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根除幽门螺杆菌逆转胃黏膜变化
实施中存在困难!
日本根除幽门螺杆菌预防胃癌的新策略
J Gastroenterol 2014: 49:1–8
Jpn J Clin Oncol. 2012;42:987-94
Seminars in Cancer Biology 23P (2013) 492-501
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高效的根除方案中必须包含高效的质子泵抑制剂
在推荐的所有根除幽门螺杆菌方案 中均含有质子泵抑制剂（PPI）
20mg bid
20mg bid