Sweetman S (Ed), Martindale: The complete drug reference. London: Pharmaceutical Press. Electronic version, (2005). OrnithineOrnithineDrug NomenclatureSynonyms: L -Ornithine ; α,δ-Diaminovaleric Acid; OrnitinarINN: OrnithineChemical name: L -2,5-Diaminovaleric acidMolecular formula: C 5H 12N 2O 2 =132.2CAS: 70-26-8Pharmacopoeias:Ger. includes Ornithine Aspartate and Ornithine Hydrochloride.Date of monograph revision: 14-Apr-1998; 02-Sep-1999; 30-Oct-2001; 25-May-2004;Drug ProfileOrnithine is an aliphatic amino acid. It is used as a dietary supplement.The aspartate, hydrochloride, and oxoglurate (ornithine ketoglutarate) have been used in various indications including the treatment of hyperammonaemia () and hepatic encephalopathy ().References.1. Kircheis G, et al. Therapeutic efficacy of L -ornithine -L-aspartate infusions in patients with cirrhosis and hepaticencephalopathy: results of a placebo-controlled, double-blind study. Hepatology 1997; 25: 1351–60. PubMed2. Stauch S, et al. Oral L -ornithine -L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study. J Hepatol 1998; 28: 856–64. PubMed3. Rapport L, Lockwood B. Ornithine ketoglutarate. Pharm J 2001; 266: 688–90. PreparationsSingle-ingredient PreparationsThe symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.Austria : Cere ; Hepa ; Ornicetil ; Braz.: Hepa-Merz¤; Chile : Hepa-Merz ; Fr.: Cetornan ; Ornicetil ; Ger.: Hepa-Merz KT ; Hepa-Merz ; Hepa-Vibolex ; Ornicetil¤; Hong Kong : Hepa-Merz ; Hung.: Hepa-Merz ; India : Hepa-Merz ; Ital.: Ornicetil S¤; Ornicetil ; Ornil KGF ; Ornil ; Spain : Ornicetil¤; Switz.: Ornicetil¤;Multi-ingredient PreparationsThe symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.Austral.: Anti-Flab¤; Braz.: Necroplex¤; Ornihepat ; Ornitargin ; Fr.: Arnilose¤; Epuram ; Ornitaine ; Ger.: Hepa-MerzSub-sections Drug Nomenclature Drug ProfilePreparationsS¤; Hepa-Merz¤; Polilevo N; Polilevo¤; India: Hepa-Merz; Hepa-Merz; Ital.: Citruplexina¤; Ipoazotal Complex; Ipoazotal; Polilevo; Somatron; Spain: Sedionbel¤; UK: Slimswift Night Trim¤;Martindale: The Complete Drug Reference © 2005 The Pharmaceutical Press.Kolassa (Austria)Active ingredients:z Ornithine aspartate (refer to Ornithine ) Indications: Hepatic encephalopathyMartindale: The Complete Drug Reference © 2005 The Pharmaceutical Press.Kolassa (Austria)Active ingredients:z Ornithine aspartate (refer to Ornithine )Indications: Hyperammonaemia associated with liver disorders Martindale: The Complete Drug Reference © 2005 The Pharmaceutical Press.Grunenthal (Chile)Active ingredients:z Ornithine aspartate (refer to Ornithine )Indications: HyperammonaemiaNOTE: Preparations with a similar name but different ingredients have been marketed in some countries. Martindale: The Complete Drug Reference © 2005 The Pharmaceutical Press.Merz (Ger.)Dose form: Injection; oral granulesActive ingredients:z Ornithine aspartate (refer to Ornithine )Indications: Liver disordersNOTE: Preparations with a similar name but different ingredients have been marketed in some countries. Martindale: The Complete Drug Reference © 2005 The Pharmaceutical Press.MIP (Ger.)Active ingredients:z Ornithine aspartate (refer to Ornithine ) Indications: Hepatic encephalopathyMartindale: The Complete Drug Reference © 2005 The Pharmaceutical Press.Merz (Hong Kong)Active ingredients:z Ornithine aspartate (refer to Ornithine )Indications: Liver disordersNOTE: Preparations with a similar name but different ingredients have been marketed in some countries. Martindale: The Complete Drug Reference © 2005 The Pharmaceutical Press.Merz (Hung.)Active ingredients:z Ornithine aspartate (refer to Ornithine )Indications: Liver disordersNOTE: Preparations with a similar name but different ingredients have been marketed in some countries. Martindale: The Complete Drug Reference © 2005 The Pharmaceutical Press.Win-Medicare (India)Dose form: Oral granules; injectionActive ingredients:z Ornithine aspartate (refer to Ornithine )Indications: Hyperammonaemia in hepatic encephalopathyNOTE: Preparations with a similar name but different ingredients have been marketed in some countries. Martindale: The Complete Drug Reference © 2005 The Pharmaceutical Press.。