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呼吸道黏膜不仅是流感病毒的感染部位,也是防御病毒感染的部位。
在流感病毒侵入机体后天然免疫系统立即作出应急反应,如果病毒逃过了非特异性免疫系统,就会被获得性免疫系统加以反应性清除。
关键词 流感病毒;黏膜感染;黏膜免疫;免疫防御机制文章编号 1673-4394(2006)05-0305-05 中图分类号 R392.1 文献标识码 AR ecent A dvances of D efense M ec hanis m s A gai n st Influenza V irus Infection i n The R espirat ory TractYANG Peng-hu i1YANG Lu-fang2(11Instit u te o f M icrobiology and Ep i d e m iology,Stafe K ey Laborator y of Pathogen and B iosecurit y,A cade my of M ilitar y M e d ical Science,B eijing100071,China;21C ollege of B iosyste m Engineering and F oo d S cience,ZheJ iang University,H angzhou310029,China)Abst ract Infl u enza v irus is a g lobally i m portant resp iratory pathogen w h i c h causes a h i g h deg ree o fm or b idity and m ortality annua lly.The respiratory tract m ucosa is not on l y the site of infecti o n for i n fluenza v iruses but a lso t h e site of defense agai n st v ir us i n fecti o n.V iruses are i n itially detected and destroyed non-specifically by i n nate i m m une m echan is m s,but if the v ir uses escape the earl y defense m echan is m s,they are detected and e li m i n ated specifica ll y by adapti v e i m m une m echan is m s.K ey w ords I n fl u enza v irus;M ucosa infection;M ucosa i m m unity;I m m un ity and defense m echanis m s aga i n st infecti o n流感是由流感病毒(Influenza v irus)通过呼吸道感染引起的重要传染病,在世界各国广泛流行。