英文论文投稿信Cover letter模板Case 1Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Cha nnels in Midbrain Dopaminergic Neurons", which we wish to be co nsidered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerat ed in Parkinson’s disease. In this paper, we report an unexpected, a cute effect of GDNF on A-type potassium channels, leading to a p otentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDN F regulates the K+ channels through a mechanism that involves acti vation of MAP kinase. Thus, this study has revealed, for the first t ime, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factorfor midbrain dopaminergic neurons, and suggest that the normal fun ction of GDNF is to regulate neuronal excitability, and consequentl y dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be conside red as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-bi nding protein frequenin mediates GDNF-induced potentiation of Ca2 + channels and transmitter release", which we wish to be considere d for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuro muscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional syna ptic transmission. Second, we show that the GDNF effect is mediat ed by enhancing the expression of the Ca2+-binding protein frequen in. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2 + influx. Thus, this study has identified, for the first time, a molec ular target that mediates the long-term, synaptic action of a neurotr ophic factor. Our findings may also have general implications in th e cell biology of neurotransmitter release.[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the exampl e used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled "Mobile Agents for Network Managem ent." Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study r eviews the concepts of mobile agents and distributed network mana gement system. It proposes a mobile agent-based implementation fra mework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please t ype in journal title or acronym])3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]?The necessity of having an effective computer network is rapidly gr owing alongside the implementation of information technology. Find ing an appropriate network management systemhas become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely r equests the status information of local units by the central server, i s not sufficient to manage the growing requests. Recently, a new fr amework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management ta sks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acron ym] readersto understand this technology and its benefits. This study gives a re al-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobil e agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].4. Names, addresses, and email addresses of four expert referees. Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster, NY 00012-6666, USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: Expertise: published a related paper ("TCP/IP and OSI: Four Strateg ies for Interconnection") in CACM, 38(3), pp. 188-198. Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123, Harbor Drive Sydney,Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail:Expertise: published a related paper ("Creating Mobile Agents") in I EEE TOSE, 18(8), pp. 88-98.Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888, Putong RoadKeelung, Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail:Expertise: published a related paper ("Network Management for E-C ommerce") in IJ Electronic Business, 1(4), pp. 18-28. Relationship: Former professor, dissertation chairman.Mr. Frank YoungPartner, ABC Consulting888, Seashore HighwayWon Kok, KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail:Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices.Relationship: I have worked with Mr. Young in several consulting projects in the past three years.Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely,Johnny SmithCOVER LETTER（投稿信）实用指南Tag：：转载时请以超链接形式标明文章原始出处和作者信息及【投稿经验】COVER LETTER（投稿信）实用指南1、什么是cover letter？指的是投稿信2、cover letter的内容主要包括那些？应该简述所投稿件的核心内容、主要发现和意义，拟投期刊，对稿件处理有无特殊要求等（如“not to review” list）。