英文论文投稿信Cover?letter模板qiusuo BY - 2006-1-17 8:59:00Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates NeuronalExcitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wishto be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbraindopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation ofneuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices.Further, we show that GDNF regulates the K+ channels through a mechanism that involvesactivation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation ofion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survivalfactor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is toregulate neuronal excitability, and consequently dopamine release. These results may also haveimplications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ.,and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequeninmediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish tobe considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers ofNeuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter releaseat the neuromuscular synapses. This provides the first physiological evidence for a role of this newfamily of neurotrophic factors in functional synaptic transmission. Second, we show that theGDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin.Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity,leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, amolecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findingsmay also have general implications in the cell biology of neurotransmitter release.[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the example used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subjectof journal] but not listed by [please type in journal title or acronym])3. Why the material is important in its field and why the material should be published in [pleasetype in journal title or acronym]The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management systemhas become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readersto understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the [journaltitle/acronym].4. Names, addresses, and email addresses of four expert referees.Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster, NY 00012-6666, USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail:Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198.Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123, Harbor Drive Sydney,Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail:Expertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98. Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888, Putong RoadKeelung, Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail:Expertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28.Relationship: Former professor, dissertation chairman.Mr. Frank YoungPartner, ABC Consulting888, Seashore HighwayWon Kok, KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail:Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices.Relationship: I have worked with Mr. Young in several consulting projects in the past three years.Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely,Johnny SmithCase 1Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates NeuronalExcitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which wewish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain, we report dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paperan unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiationof neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices.Further, we show that GDNF regulates the K+ channels through a mechanism that involvesactivation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as along-term survival factor for midbrain dopaminergic neurons, and suggest that the normalfunction of GDNF is to regulate neuronal excitability, and consequently dopamine release.These results may also have implications in the treatment of Parkinson’s disease. Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ.,and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequeninmediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which wewish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers ofNeuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitterrelease at the neuromuscular synapses. This provides the first physiological evidence for arole of this new family of neurotrophic factors in functional synaptic transmission. Second, weshow that the GDNF effect is mediated by enhancing the expression of the Ca2+-bindingprotein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancingCa2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic actionof a neurotrophic factor. Our findings may also have general implications in the cell biology ofneurotransmitter release.[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the example used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as acandidate for publication in the [journal title]. Below are our responses to your submissionrequirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts ofmobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate thesuperior performance of a mobile agent-based network over the conventional client-serverarchitecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to[subject of journal] but not listed by [please type in journal title or acronym])3. Why the material is important in its field and why the material should be published in[please type in journal title or acronym]The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management systemhas become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of localunits by the central server, is not sufficient to manage the growing requests. Recently, a newframework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readers。