Major affiliations:
Institute for Molecular Bioscience, University of Queensland Institute of Cancer Sciences, University of Glasgow
实验样本——456例PCs
Tab. 3: Histosubtypes of 382 APGI group
Subtypes
Squamous Pancreatic progenitor Immunogenic Aberrantly differentiated endocrine exocrine
Journal
Nature 2016
Subtypes of pancreatic ductal Classical adenocarcinoma and their differing Quasimesenchymal responses to therapy Exocrine-like Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma ‘basal-like’ and ‘classical’ tumor subtype ‘normal’ and ‘activated’ stromal subtypes
Gastroenterology 2015
Outline
Tab. 1: Whole genomes redefine the molecular landscape of pancreatic cancer
Title
Genomic analyses identify molecular subtypes of pancreatic cancer
组织学类型 病例数
PDAC 与导管腺癌相关的变型
IPMN 腺泡细胞癌 其他
319 31
27 2 3
Tab. 4: 74 previously published PC exomes
Nature medicine 2011
Nature genetics 2015
Peter Bailey et al. Nature 2016, doi:10.1038/nature16965
Genomic analyses identify molecular subtypes of pancreatic cancer
Richard A Moffitt et al. Nature genetics 2015. doi:10.1038/ng.3398
Outline
Tab. 1: Whole genomes redefine the molecular ladscape of pancreatic cancer
Title
Nature medicine 2011
Nature genetics 2015
Outline
Tab. 2: Identify driver mutations of pancreatic neoplasms
Title Whole genomes redefine the mutational landscape of pancreatic cancer Subtypes Stable Locally rearranged Scattered Unstable Distant metastasis occurs late during the genetic evolution of pancreatic cancer A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts Nature 2010 Journal Nature 2015
Journal
Nature 2016
Subtypes of pancreatic ductal Classical adenocarcinoma and their differing Quasimesenchymal responses to therapy Exocrine-like Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma ‘basal-like’ and ‘classical’ tumor subtype ‘normal’ and ‘activated’ stromal subtypes
Molecular subtyping of pancreatic carcinoma
Jie Chen Peking Union Medical College Hospital , CAMS & PUMC
Background
Fig 1. Approximate frequencies of mutations in patients with PDAC and IPMN.
Genomic analyses identify molecular subtypes of pancreatic cancer
Subtypes
Squamous Pancreatic progenitor Immunogenic Aberrantly differentiated endocrine exocrine
David P. Ryan et al. NEJM 2014. do8
Background
Fig 2. Schematic depicting the major cell types in primary tumor and liver metastatic samples.