2020/10/18
5
2. Immune system (IS)
-
ponents of immune system B.Functions of immune system
2020/10/18
6
ponents of IS
immune organs
immune cells
immune molecules
site of T cell differentiation and mutulation
induce autoimmune tolerance
take 2020/10/18 part in immunoregulation
9
lymph nodes 75% ---T
25%---B
*structure
2020/10/18
4
B.Antigen, antibody and immune
response
Combine with
Pathogen or toxic product
body
Specific substance
Ag
Ab
Ag→ → →body → → →Ab
(IS)
抗原刺激机体(免疫系统)产生抗体的全过程 称为免疫应答(immune response,IR)
white pulp red pulp
*function
•T,B细胞定居和
产生免疫应答 的 场所
•过滤血液 •合成免疫活性
物质的重要场所
被膜
边缘带
白髓 (淋巴鞘)
生发中心 脾索 (B cell,M,DC)
(淋巴滤泡) 红髓
静脉窦
入脾动脉
小动脉周
围淋巴鞘 (T cell areas)
淋巴小结的
生发中心 (B cell areas)
cortex
shallow cortex (B cell areas)
paracortex (T cell areas)
medulla
medullary cords 髓索
(T,B,plasma cell and M) medullary sinus 髓窦
*function of thymus
8
thymus
---
胸腺小叶的结构
*structure of thymic lobule outer cortex inner medulla
*contain thymocytes and thymic stromal cells(TSC)
*function of thymus
TSC including: • thymus epithelial cells • macrophage • thymus dendritic cells • fibroblast
sites of residence and developing immune
response for T and B cell
filter lymph
take 2020/10/18 part in lymphocyte recirculation

spleen 55%---B
35%---T
*structure
2020/10/18
7
bone marrow *sourse of various blood cells
*site of B cell differentiation and mutulation
*site of developing response mediated by B cell
2020/10/18
Immune molecules
secritory molecule (Ig,Complement,Cytokine)
membrane molecules
(TCR,BCR, MHC molecule, CKR ,CD
2020/1m0/18olecule, AM,CR and so on.)
13
B. Function of IS reject
*function
• 执行固有免疫 • 分泌SIgA , 执行局部特异性免疫功能的主要场所 • 参与口服抗原介导的免疫耐受
2020/10/18
12
Immune cells
---所有参与免疫应答或与免疫应答有关的细胞及其前 体,均属于免疫细胞
hematopoietic stem cells(HSC) phagocytes lymphocytes(T,B and NK cells) antigen-presenting cell (APC) other cell
Immune organs
•central immune organ
---bone marrow and thymus
•peripheric immune organ and tissues
---lymph nodes and spleen
•mucosal-associated lymphoid tissue
2020/10/18
3
1. Major conception
A. Immunity
(immunis)
Classical conception
---机体防御病原体侵袭的能力 (或抗感染的防御能力)
Modern conception
免疫是机体识别自己和非己, 并排除 非己抗原, 以维持机体内环境稳定的生理 性防御功能;正常情况下具有保护作用,异 常情况下可损害机体 （双重性）
边缘带
中央小动脉 (B cell,T cell)
2020/10/18
第一课件网网站
11
Mucosal immune system(MIS)
(or mucosal-associated lymphoid tissue, MALT)
*consists of unencapsulated subepithelial lymphoid found in the gastrointestinal, respiratory and urogenital tracts
第一课件网网站
医学微生物学 (46)
医学免疫学 (28)
医学寄生虫 (24)
药理学
(12)
2020/10/18
1
2020/10/18
2
Chapter 1,2
1.Major conception
2.Immune system
3.Type of immune response
4.The History of immunology