Pancuronium

Dosage
For intubation :0.08-0.12mg/kg For intraoperative:0.04mg/kg 20-40min 0.01mg/kg

Side effects and clinical considerations:
It must be stored at 2-8℃. Hypertension and tachycardia Allergic reactions Dysrhythmias
Cistracurium
Dosage For intubation :0.1-0.15mg/kg within 2min For infusion:1-2µ g/kg/min Side effects and clinical considerations: Laudanosine toxicity, pH and temperature sensitivity, and chemical incompatibility (alkaline solution such as thiopental precipitate)

Mivacurium

Dosage
For intubation :0.1-0.2mg/kg For infusion:4-10µ g/kg/min

Side effects and clinical considerations:
Doxacurium(多沙氯铵)

Dosage
For intubation :0.05mg/kg within 5min For intraoperative:0.02mg/kg 0.005mg/kg
Metocurine甲筒箭毒

Dosage
For intubation :0.3mg/kg For intraoperative:0.08mg/kg 0.03mg/kg

Side effects and clinical considerations:
Hypotension tachycardia ,bronchospasm ,allergic reactions
Tubocurarine(筒箭毒碱)

Dosage
for intubation:0.5-0.6mg/kg for intra-operative: 0.15mg/kg 0.05mg/kg

Side effects and clinical considerations:
hypotension and tachycardia

Succinycholine

Dosage:
1-1.5mg/kg, repeated small dose 10mg or 1g in 500 or 1000ml, titrated to effect

Side effects and clinical considerations:
A. Cardiovascular B . Fasciculations C. Hyperkalemia D. Muscle pains E. Intragastric pressure elevation F. Intraocular pressure elevation G. Generalized contractions H. Prolonged paralysis I. Intracranial pressure
Atracurium

Dosage
For intubation :0.5mg/kg For intraoperative:0.25mg/kg 0.1mg/kg every 10-20min

Side effects and clinical considerations:
It must be stored at 2-8℃. laudanosine (N-甲基四氢罂粟碱)toxicity
术中知晓（awareness）是一种严重 的全麻术中并发症，会给病人造成巨大 的精神损害。尤其易发生于肌松药应用 不当的全麻麻醉中。
临床常用肌松药
去极化肌松药 琥珀胆碱suxamethonium,succinylcholine ,scoline 非去极化肌松药 潘库溴铵pancuronium,pavulon 维库溴铵vecuronium 阿曲库铵atracurium,tracrium 哌库溴铵pipecuronium 罗库溴铵rocuronium 美维松mivacurium
Hale Waihona Puke Side effects and clinical considerations: Devoid of cardiovascular and histaminereleasing side effects. Duration time:60-90min Onset time slower :4-6min
Vecuronium
Dosage For intubation :0.08-0.12mg/kg For intraoperative:0.04mg/kg 0.01mg/kg every 1520min For infusion:1-2µ g/kg/min Side effects and clinical considerations: Devoid of cardiovascular effects Liver failure

Pipecuronium

Dosage
For intubation :0.06-0.1mg/kg
Side effects and clinical considerations:
Compared with pancuronium ,pipecuronium devoid of cardiovascular and histamine release side effects, onset of action and duration of action are similar for both drugs
肌松药的临床应用The clinical
use of neuromuscular blockade
概 述
肌松药是全麻中重要的辅助用药 肌松药是麻醉药吗？ 不是 1942年以前…… 深麻醉---良好肌松 1942年箭毒应用于临床，临床麻醉就发生了革 命性的变化： 浅麻醉+肌松药-----良好肌松
Awareness