英文论文投稿信Cover letter模板Case 1Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassiu m Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium cha nnels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of G DNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiatio n of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GD NF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physi ological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show th at the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequ enin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, thi s study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic fact or. Our findings may also have general implications in the cell biology of neurotransmitter release.[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the example used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed netw ork management system. It proposes a mobile agent-based implementation framework and creates a prototype system to de monstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a larg e network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym])3. Why the material is important in its field and why the material should be published in [please type in journal title or acron ym]?The necessity of having an effective computer network is rapidly growing alongside the implementation of information technol ogy. Finding an appropriate network management systemhas become increasingly important today's distributed environment. However, the conventional centralized architecture, which r outinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes ma nagement tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readersto understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distribute d network management. It is the first in the literature that reports the analysis of network performance based on an operatio nal prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].4. Names, addresses, and email addresses of four expert referees.Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster, NY 00012-6666, USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail:Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198. Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123, Harbor Drive Sydney,Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail:Expertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98.Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888, Putong RoadKeelung, Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail:Expertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28. Relationship: Former professor, dissertation chairman.Mr. Frank YoungPartner, ABC Consulting888, Seashore HighwayWon Kok, KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail:Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices. Relationship: I have worked with Mr. Young in several consulting projects in the past three years.Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely,Johnny Smith•COVER LETTER（投稿信）实用指南Tag：投稿相关版权声明：转载时请以超链接形式标明文章原始出处和作者信息及本声明【投稿经验】COVER LETTER（投稿信）实用指南1、什么是cover letter？指的是投稿信2、cover letter的内容主要包括那些？应该简述所投稿件的核心内容、主要发现和意义，拟投期刊，对稿件处理有无特殊要求等（如“not to review” list）。