Lhermitte’s sign; ⑦ Attack syndrom ⑧ Other clinical feature
boratory and other assistant Tests
1. CSF Test
1) Number of MNC<15 106/L
2) IgG-Index > 0.7; oligoclonal bands(OB) positive;
diseases of CNS.
2. Etiology And Pathogenesis
1)病毒感染及自身免疫反应：麻疹病毒、 人类噬 T 淋巴细胞病毒( HTLV-I) 分子模拟、细胞免疫、体液免疫(1,2,3,4) 2)遗传因素 (inherited factor) 3)环境因素 (environment)(4)
3) MBP, PLP, MAG, MOG Abs and Ab-secreting cells
4) CSF-Alb/serum-Alb>1.7(probability of MS)
④ A relative integrity of the axis cylinders in the lesions and a lack of wallerian, the secondary degeneration of fiber tracts.
多发性硬化
Multiple Sclerosis
Acute stage: hyperemia,ondema,demyelination, infiltration of inflammatory cells in perivascular distribution.
Recovery stage : Astrocyte proliferition, forming of astrocytic scab.
Heredity may be an important factor.
MS associated with the HLA-DR locus on the sixth chromosome, HLA-DR2 express strongly and then -DR3 , B7 and A3 .
4. Pathologic Findings
Characteristic: Multiple demyelinated plaques in white matter of CNS.
Position: White matter around the lateral ventricles and spinal cord, optic nerve, brain stem and cerebellar.
3) Early symptoms and signs: ① Weakness or numbness, sometimes both, in one or more limbs is the initial symptom in about half of the patients;
Hale Waihona Puke ② The visual loss in one or both eyes; ③ Nystagmus(fig1) and palsy of eye
小脑及桥脑脱髓鞘病灶
桥脑脱髓鞘病灶
5. Clinical Manifestations
1) Prodrome: The symptoms evolved more slowly, over several weeks or months.
2) Acute or subacute onset Relapsing-remitting.
1. Concept
Multiple Sclerosis is a kind of autoimmune diseases characterized by demyelination of CNS. Due to its high incidence, chronicity and tendency to attack young adults, it has become one of the most important
中枢神经系统脱髓鞘疾病
Demyelinating Diseases of the Central Nervous System
哈医大二院神经科
Chapter 1 Intraduction
1. Concept A group of diseases of the
brain and spinal cord in which demyelination is a prominent feature.
3. Epidemiology
Incidence of MS associated with latitude. Contacting with some kind of environment
may play an important role in the incidence of MS.
muscles (internuclear ophthalmoplegia, one and a half syndrome) ④ Impairment of other brain nerves; ⑤ Ataxia: Charcot’s syndrom ⑥ Sensation disorder: Romberg’s sign,
2. Pathologic Findings
① Destruction of the myelin sheaths of nerves;
② Infiltration of inflammatory cells in a perivascular distribution;
③ A particular distribution of lesion, often perivenous and primarily in white matter, either in multiple small disseminated foci or in larger foci ;