Department of Immunology
Define of Immunology IMMUNE FUNCTIONS ---immune defence (infectious disease)
--- immune surveillance
--- immune homeostasis
Department of Immunology
Song dynasty A divine doctor Emei Mountain 1798 1880 1890 Jenner Pasteur Behring/Kitasato Vaccination
Attenuated chicken cholera vaccine Antitoxin ―Humoralimmunity hypothesis
Department of Immunology
Department of Immunology
Established in the autumn of 1987, one of the first
University Departments in the world devoted specifically to the study of the immune system. (Yale, in 1988)

2 Centuries to Eradicate Small Pox
Greatest Triumph in Modern Medicine

Department of Immunology
History of Immunology
The announcement by the WHO in 1980 that smallpox was the first disease that had been eradicated worldwide by a program of vaccination
Department of Immunology
History of Immunology
Thucydides (430 BC)
Plague of Athens
“Yet it was with those who had recovered from the disease that the sick and the dying found most compassion. These knew what it was from experience, and had now no fear for themselves; for the same man was never attacked twice - never at least fatally” Resistance to re-infection-Immunity
Define of Immunity
Immunity refers to mechanisms used by the body as protection against environmental agents that are foreign to the body Microorganisms
Department of Immunology
History of Immunology
Department of Immunology
WHAT is the immune system?
Complex defense system
Physiological function is to

Foods
Chemicals, Drugs, Pollen etc.
Department of Immunology
History of Immunology
Smallpox
Smallpox is a disease caused by the Variola major virus. Smallpox spreads very easily from person to person. Symptoms are flu-like and include high fever, fatigue and headache and backache, followed by a rash with flat red sores.
Medical Immunology
Department of Immunology
Yiwei Chu
ywchu@
2010-4-19
Medical Immunology
One of the six-year undergraduate professional
courses Overview of the immune system, immune response and regulation, immune diseases Basic immunological theory (theory course)
1883
1905 1945 1959
Metchnikoff
Pirquet/Schick Owen/Burnet Burnet
Endocytosis - Cytoimmunity hypothesis
Horse serum sickness (Hypersensitivity) Immune tolerance hypothesis Clonal selection hypothesis
History of Immunology Edward Jenner

Chinese-Variolation

Prophylactic measure against Smallpox

1798-Cow Pox/Vaccinia Induced Protection Against Small Pox-Vaccination
3. Adaptive Immune Responses
Department of Immunology
History of Immunology
IMMUNITY ←← IMMUNIS (EXEMPT)
Derived from the Latin word
Protection from legal prosecution Now, in medical terms, it denotes resistance to reinfection/free of disease.
Prevent infections
Eradicate established infections
Self/Nonself discrimination
Department of Immunology
Who has an immune system?
ALL animals.
Vert-Invert systems: analogous Various vert systems: homologous
Department of Immunology
Who has an immune system?
Department of Immunology
Severe Fungal Infection in a Fruit Fly.
Department of Immunology
How Does Immune System Work?
Bo Gao
Haifeng Gao
Department of Immunology
Chapter 1
General Properties of Immune Responses
Department of Immunology
Content
1. History of Immunology
2. Innate and Adaptive Immunity

Emil Adolf von Behring, 1854-1917 A German bacteriologist
Department of Immunology
History of Immunology
430 B.C. Thucydides
People have been sicked free from illness Variolation
History of Immunology
Edward Jenner memorial hall
Edward Jenner(1749－1823)
Department of Immunology
History of Immunology
Preparation of smallpox
Department of Immunology
Department of Immunology
History of Immunology
Department of Immunology
History of Immunology
Louis Pasteur (1822-1895) 1880 Vaccine 1881 Vaccine to Anthrax 1885 Vaccine to Rabies
A strong team with rich experiences in teaching and
research
Department of Immunology
Department of Immunology
Yiwei Chu
Rui He
Wei Xu
Yunlu Lin Qing Lu Xiaowu Hong
Immunochemical and cellular techniques
(experimental course)