Case 1Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I am Sincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.某杂志给出的标准Sample Cover LetterCase 3Sample Cover LetterDear Editor of the :Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the . Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to but not listed by )3. Why the material is important in its field and why the material should be published in ?The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management system has become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the readersto understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the .4. Names, addresses, and email addresses of four expert referees.Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster, NY 00012-6666, USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: ********************Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198.Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally. Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123, Harbor Drive Sydney,Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail: *************.auExpertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98. Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888, Putong RoadKeelung, Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail: *************.twExpertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28.Relationship: Former professor, dissertation chairman.Mr. Frank YoungPartner, ABC Consulting888, Seashore HighwayWon Kok, KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail: ***************Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices.Relationship: I have worked with Mr. Young in several consulting projects in the past three years. Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely,Johnny SmithDear ***We are submitting our manuscript entitled “~~~~”, ~~ pages with ~~ figures, for your kind consideration of its suitability for publication in ~~~~. The manuscript has not been previously published, is not currently submitted for review to any other journal, and will not be submitted elsewhere before a decision is made by this journal. In addition, a justification for the publication in Journal of Power Sources is enclosed.A paragraph explaining why our manuscript is appropriate for ~~~（此处讲你工作的优点和创新点在哪里，吹一吹）. Therefore, we respectfully submit this paper and hope it may first be published for ~~~Sincerely yours,Dear Mr. **1. The work described has not been submitted elsewhere for publication, in whole or in part, and all the authors listed have approved the manuscript that is enclosed.2. I have read and have abided by the statement of ethical standards for manuscripts submitted to Neuroscience.kind regards.Your sincerely,通讯作者常用模板（2）Dear Dr. 主编name:We submit our manuscript entitled " 文章title" to 杂志名for publication.接着简单介绍你文章的主要创新点和意义，不易过多，但要突出新意和关键点。