• Metastasis - cancer cells penetrate into lymphatic system and blood vessels
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Acquiring Invasiveness
Primary carcinoma cell(s) must: •Disengage from their neighboring epithelial cells •Become motile •Degrade the surrounding extracellular matrix
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Tumor metastasis is a complex, multistep process consisting of a series of discrete biological processes.
Figure 14.4 The Biology of Cancer (© Garland Science 2007) p. 591
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Bone Metastasis
复旦大学上海医学院肿瘤学系
Lung Metastasis
Fudan University Cancer Center
Brain Metastasis
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Multistep Process of Metastasis
Metastasis is influenced by the interactions between
Tumor cells and host cells Immediate and extended
Fudan University Cancer Center
Origin and History
• The oldest and one of the most prestigious cancer centers in China
• Founded in 1931 as SinoBelgium Radium Institute by Kingdom of Belgium
Soft tissue sarcoma in left leg
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
alveolar soft part sarcoma in left leg
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center 复旦大学上海医学院肿瘤学系
-understanding how cells disseminate from the primary tumor to invade and successfully colonize distant tissues represents the LEAST understood and the most deadly area of cancer biology.
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Invasion and Metastasis
• cancer cells proliferate and spread (metastasize) to other parts of the body
• Invasion - direct migration and penetration into neighboring tissues
Metastatic carcinoma of the ovary from the stomach
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Classic Type
Classic Type
复旦大学上海医学院肿瘤学系
Sclerosing Type
Tubular Type
Widely used is a so-called TNM system.
复旦大学上海医学院肿瘤学系
T: Primary Tumor T1, T2, T3, or T4, with increasing size of primary lesion
N: regional lymph node involvement No, N1, N2, N3 to indicate progressively advancing nodal disease
Fudan University Cancer Center
Basic Clinical Oncology
The Cellular Microenviroment and Metastases
Fudan University Cancer Center
Prof. Dr. Wentao YANG
复旦大学上海医学院肿瘤学系
University since 2000
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Basic Clinic Oncology
Course Objectives:
• To know the etiology and biology of cancer and the situation of cancer prevention.
Pulmonary blastoma metastasiFzuedtaonrUignhivterosvitayrCyancer Center
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Metastatic carcinoma of the ovary from the colon
Definition of Metastasis
The process whereby malignant tumors spread from their site of origin (the primary tumor) to form tumors at secondary sites (secondary tumor) .
Fudan University Cancer Center
Lung
复旦大学上海医学院肿瘤学系
alveolar soft part sarcoma
Fudan UniversFra bibliotekty Cancer Center
Malignant Phyllodes Tumor of the Breast
复旦大学上海医学院肿瘤学系
• To know the frontiers of basic and clinical researches briefly
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center 复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Fudan University Cancer Center 复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Malignant Phyllodes Tumor metastasize to the lung
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Acquisition of the capability for invasion and metastasis is the hallmarks of cancer.
Metastasis remains the major driver of mortality in patients with cancer.
Motility and tissue invasion Intravasation (Alternatively, can enter lymphatic vessels) Survival in the blood stream (trauma, immune cells, oxygen levels, growth factor availability etc.) Arrest at new location Extravasation Attraction/induction of new stromal cells (may occur BEFORE metastasis occurs). Growth and Proliferation…. Angiogenesis
From Blaustein’s Pathology of the Female Genital Tract
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center 复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Metastatic carcinoma of the ovary from the appendix
• Formerly affiliated to Shanghai Medical University (1954-2000)
复旦大学上海医学院肿瘤学系
Fudan University Cancer Center
Sino-Belgium Radium Institute in 1950