特别声明
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is a hallmark of all major cancers including those of the prostate, the breast, the colon, and the ovaries. In prostate cancer PC-3 cells, ML-356 blocked palmitate (the final product of fatty acids synthesis) biosynthesis, indicating that ML-356 has potential to block tumor growth in vivo because FAS is up-regulated in all the major solid tumors. 参考文献: 1. R. Ardecky, M. P. Hedrick, P. Gosalia, et al. Selective inhibitors of FAS-TE. Probe Reports from the NIH Molecular Libraries Program (2010).
产品说明书
化学性质
产品名: Cas No.: 分子量: 分子式:
ML-356 1808260-45-8 423.5 C19H25N3O4S2
产品名: ML-356 修订日期: 6/30/2016
化学名:
SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
2-ethyl-N-[4-[4-(4-morpholinylsulfonyl)phenyl]-2-thiazolyl]-butanam ide
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Others
信号通路:
FAS
产品描述:
ML-356 is an inhibitor of the thioesterase domain of fatty acid synthase with IC50 value of 334 nM. Fatty acid synthase (FAS) is a multi-enzyme protein that catalyzes fatty acid synthesis, fatty acids are related to energy production and storage, cellular structure ,hormones biosynthesis .A number of subsequent immunohistochemically analyses showed that increased expression of FAS
ApexBio Technology
O=S(C1=CC=C(C2=CSC(NC(C(CC)CC)=O)=N2)C=C1)(N3CCO20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.