French Pinel “madhouse”——hospital
the mid-nineteenth century:
In 1857，French Morel: Dementia
(Loss of Mind) In 1871, Germany Hecker: Praecox (Early, Premature) In 1874,Germany Kahlbaum: Catatonia In 1896,Germany Kraepelin: “Dementia Precox”/“Youth Dementia” Categorization & Early Onset In 1911,Switzerland Eugen Bleuler Termed ―Schizophrenia‖ Associative Splitting
Onset is usually in late adolescence Substance abuse is a co-morbid condition in 50% of schizophrenia patients
Broad Impairments Delusions & Hallucinations
organic ? mental disorders
? functional ? mild ? major
neurosis •Schizophrenia •Mania-depression
•Other psychotic
disorders
3. Clinical features
2. Epidemiology 1. Definition
“One Flew Over the Cuckoo's Nest”
(1) Perception (2) Thought & association (3) Affect (4) Volition (5) Other disturbances
Worldwide
※ Lifetime prevalence rate in adult: 1% ※ Peak age: 15-24(M)，25-29(F) ※ Gender:M:F=1：1.6 ※ Economy(-), rural>urban
※ Currently 8 million nationwide，annual growth 300 thousand，10% violence tendency
Outcome： •50% ----- try to suicide •10% ----- died (due to self-killed)
Chlorpromazine/ CPZ
N
2
Other psychosis
20%
80%
1
schziophrenia
3. Clinical Features
4. Subtypes PART1:Schizophrenia 8. Treatment 5. Etiology & pathogenesis 6. Diagnosis & differential diagnosis 7. Course & prognosis
1. Definition of schizophrenia
Schizophrenia
[ˌskitsəuˈfri:niə]
YuYu（Fanny） Xiangya hospital of CSU
What is Schizophrenia?
Schizophrenia is a mental disorder characterized by a disturbance of thought, emotion and behavior. The lifetime prevalence of schizophrenia is about 1%
Schiz(separation)
Phrenia
Spirit cancer
• A group of psychotic disorders of unknown specified etiology
• Presented with a gradual onset of abnormalities in perception, thought, emotion & behavior
•consciousness : maintained
•intelligence : intact •natural course :chronic remitting but some times deteriorating
2. Epidemiology of schizophrenia
•How common is schizophrenia?
Disorganized Speech & Behavior
Inappropriate Emotions Psychosis: extreme mental unrest with

loss of reality contact (Davison & Neale, p. 134)
review
Medieval （A.D. 476 years to the seventeenth century）： Theological and religious influence:“witch persecution”and“Stupid stone”
Modern times（The late 17th century to the18th ）：
clinical manifestation are Complicated & Diverse
No one case can show all the symptoms
Symptoms
Hallucinations Most reported are hearing voices Delusions Often bizarre or persecutory in nature Thought disorder Disorganized thinking and speech