心脏移植、肺移植及心肺联合移 植的历史和现状
发展历史
➢Alexis Carrel- 1907 ,血管缝合技术，器官保护研究，为现代器官 移植奠定了基础。1912年诺贝尔医学及生理学奖
➢Demikhov- 1940s，In 1946，the first to perform a heart transplant on a dog.
Bruce Reitz
1983- Cooper- first successful lung transplant 1985- Cooper / Patterson- double lung transplant
Cooper
Patterson
Dr.Vaughn Starnes-1993, the first living lobar lung transplantation in USC
国内
辛育龄， 1979，第一例肺移植 陈玉平，安贞医院， 1995，第一例成功单肺移植
1998，第一例成功双肺移植 第一例心脏移植：1978，109天 夏求明，哈医大，1992，>18年 心脏移植1000+ 肺移植300+ 心肺联合移植20-
REGISTRY DATABASE:
Number of Transplants Reported
➢Lower/ Shumway- 1960s ，report successful heart transplant on dog ➢Hardy-1963, first human lung transplant ➢Christian Barnard -1967, the world's first heart transplant on a patient , 18days
3,550
49,642
2014
JHLT. 2014 Oct; 33(10): 975-984
REGISTRY DATABASE:
Number of Transplants Repransplants Reported from July 1, 2012,
through June 30, 2013
ISHLT
2012
J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095
REGISTRY DATABASE:
Number of Centers Reporting Heart-Lung Transplants
ISHLT
2012
J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095
Number of Centers Reporting Heart Transplants
ISHLT
2012
J Heart Lung Transplant. 2012 Oct; 31(10): 1045-1095
REGISTRY DATABASE:
Number of Centers Reporting Lung Transplants
手术适应症
DIAGNOSIS IN ADULT HEART TRANSPLANTS
CAD 44%
ReTX 2%
Misc. 3%
Valvular 3%
Congenital 2%
Myopathy 46%
1/1982-6/2008
CAD 38%
ReTX 3%
Misc.
4% Valvular
2%
Congenital 2%
JHLT. 2014 Oct; 33(10): 975-984
REGISTRY DATABASE:
Number of Centers Reporting Transplants
ORGAN Heart
Centers Ever Reporting Data
Centers Reporting Transplants
1922-2006
1922-2001
➢Shumway-1968, On Jan. 6, Shumway and his surgical team perform the first successful adult human heart transplant in the United States ,14 days ➢Denton Arthur Cooley -1968, the first heart surgeon to inplant
an artificial heart designed by Dr Domingo Liotta in a man
1920-
➢ Shumway and Bruce Reitz- 1981, perform the world's first successful combined adult human heart-lung transplant.
in 2002
Centers Reporting Transplants between 1/2012 and 6/2013
416
260
256
Heart-Lung
168
54
42
Lung
241
128
146
2014
12
JHLT. 2014 Oct; 33(10): 975-984
REGISTRY DATABASE:
Myopathy 51%
1/2005-6/2008
70
60
Myopathy
CAD
50
40
30
20
% of Cases 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
ORGAN Heart
Transplants Reported Total Transplants from July 1, 2012, Reported through
through June 30, 2013 June 30, 2013
3,809
116,104
Heart-Lung
66
4,488
Lung
Adult Pediatric
Total Transplants Reported through
June 30, 2013
Adult Pediatric
3,300
508
104,027 11,694
Heart-Lung
56
10
3,772
694
Lung
3,453
97
47,647 1,985
2014
11