A.Mitogen receptor
--- Various membrane molecules of
recognizing mitogen on the surface of
T cell
PHA-receptor (植物血凝素受体)
ConA- receptor (刀豆蛋白A受体)
B.Mitogen binding to mitogen receptor →activation, proliferation and transformation of T cell
➢Lymphocytes
T cell and B cell
NK cell
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T Lymphocytes and B Lymphocytes
• Major cells participated in specific immune response
• Common characteristics
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Ⅱ.Subsets and Function of T Cells
1.TCR T cell ＆TCR T cell 2.CD4+T cell ＆ CD8+T cell
3.Th,Tc,Ts and TDTH cell
• CD40L- -CD40 →co-stimulatory signal of activation for B cell • C20T20年L1A0月-24日--B7.1/B7.2→suppressive signal for activative T cell 8
4. Mitogen receptor
Chapter 9
第一课件网网站
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Introducion
➢ Immune cells
Specific immune response cells ( T cell、B cell and APC )
Non-specific immune response cells
(phagocyte,NK cell,T cell and B1 cell)
Structure
---heterodimer that consists of chain and chain (or chain and chain) linked by disulfide-bonds
or TCR
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Belong to members of IgSF
---each chain consists of a V and a C
*heterogenicity (异质性) *ability for recognizing Ag (TCR / BCR) *can induce specific immune response
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➢Surface marker ➢Subsets and function ➢Development process of T cell
---CD2+ 、 CD3+ 、TCR+
Recognize antigen
---only recognize antigen peptideMHC complex
region on the extramembrane region
B. CD3 molecule ( ,,, and chain)
5
C.TCR-CD3 complex
---made up of TCR and CD3 molecules
V V
Common model
•TCR-CD3(80%~90%) •TCR-CD3
Function
• CD3:transmit activating
signal
ITAM
/
• TCR:only recognize antigen peptide-MHC complex
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2.CD4 and CD8 molecule
A. Co-receptor of T cell B. Function
enhance adhension of T cell with APC or target cell(靶细胞)
participate in signal transduction
CD8+T
T cell
V V
靶细胞
3.Costimulating signal molecules
CD4+T V V
2
APC
5%~15% 皮肤,粘膜丰富
TCR多样性
极高
低
识别抗原 8~17个氨基酸 简单多肽/脂类/HSP/多糖
功 能 参与IR的主要亚群 非特异性杀伤
(抗胞内感染,抗肿瘤)
Th
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CTL
CTL, TCR T 11
2.CD4+T cell ＆ CD8+T cell
Common surface marker
4.Naive T cell & memory T cell 5.NK1.1+ T cell
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1.TCR T cell ＆ TCR T cell
TCR+T細胞 TCR+ T細胞 p85
不同标志 CD4+或CD8+
CD4-,CD8-/CD8+
分布
外周血 组织
60%~70% 外周淋巴组织
in the thymus
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Ⅰ.Surface marker of T cell
TCR
V V
C C
1.TCR-CD3 complex
A.TCR (TCR/TCR)
---Characteristic marker of all T cell and specific receptor of recognizing Ag

---CD28,CD2,LFA-1 and CD40L
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3.Co-stimulating signal molecules
CD40L
(LFA-2)
CD40
(B7.1/B7.2) (CD58)
(CD28-B7最重要)
APC
• CD28,CD2 and LFA-1 binding to ligand on the surface of APC →costimulating signal of activation for T Cell