的相对意义
➢ Study object of genetic
epidemiology ➢ 遗传流行病学的研究对象 ➢ Study contents of genetic
➢ 遗传流行病学的研究内容
epidemiology
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一、遗传流行病学的概念 The concept of genetic epidemiology
• Multi-gene genetic diseases
• largely determined by environmental factors
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人为地将多基因遗传病划分为： • 高遗传度多因子疾病
Multi-factorial diseases with a high heritability • 低遗传度多因子疾病 Multi-factorial diseases with a low heritability
第三节 遗传性疾病的预防 Prevention
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第一节 概述
Overview
➢ 遗传流行病学的概念
➢ The concept of genetic
epidemiology
➢ 疾病病因中遗传与环境 ➢ The relative significance of
genetic and environmental
种瓜得瓜
Department of Epidemiology Public Health College of Harbin Medical University
种豆得豆
种瓜得豆 种豆得瓜
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内容概况 Content Overview
第一节 概述
Overview
第二节 遗传流行病学的研究方法 Study method
遗传流行病学
Department of Epidemiology Public Health College of Harbin Medical University
遗传
• 我是家族赐予的面庞 • 肉体消逝，而我依
在— • 任时光荏苒 • 地域轮转 • 我独有的特性和模样 • 永不消亡
Heredity
The relative significance of genetic and environmental
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（一）随着病因研究的 深入，一些过去认单纯 由遗传因素引起的疾病 可能与环境因素有关。
Some disease solely caused by genetic factors in the past, environmental factors may be related now.
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“连续的病因学谱”
continuing cause spectrum
遗传
Genetic
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环境
Environmental
三、研究对象－与遗传有关的疾 病
Object of study - and genetic-related diseases
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➢单基因遗传病 Single-gene genetic diseases
征 藐视生的禁限 代代相传—— 这就是我：人之永恒 全然不顾死神的召唤
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The years-heired feature that can In curve and voice and eye Despise the human span Of durance — that is I; The eternal thing in man, That heeds no call to die.
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（二）一些过去认为完全 由环境因素所致的疾病 也可能与遗传因素有关， 并且近年研究不但证实 了这类疾病的遗传基础， 而且确定了其易感性， 进行了基因定位。
Some disease were thought caused by environmental factor completely, may related with genetic factors. Not only the genetic basis are confirmed, the genetic susceptibility are also approved, and location were find.
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疾病分类 Classification of Diseases
1、由遗传因素决定的疾病
2、基本上由遗传因素决定 的疾病
3、多基因遗传病
4、基本上由环境因素决定 的疾病
• determined by genetic factors
• largely determined by genetic factors
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着重研究疾病发生 中遗传因素与环境因 素所起的作用，作用 的方式、后果和预防 the role of genetic and environmental factors, the way of effect, the outcome and methods for prevention
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（一）定 义 Definition
➢研究与遗传有关的疾病在人群中的分 布、病因、以及制订预防和控制对策 的学科。
Subject which researches distribution of genetic-related diseases in the population, etiology, develops
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（二）与其他概念的区别
The difference with other concepts ➢医学遗传学 Medical Genetics ➢群体遗传学 Population Genetics ➢传统流行病学 Traditional epidemiology
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二、疾病病因中遗传与环境的相对意义
➢多基因（因子）遗传病 Multi-gene genetic diseases
I am the family face; Flesh perishes, I live on Projecting trait and trace Through time to
times anon, And leaping from place to
place Over oblivion
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嗓音、眼神 脸廓上岁月承继的特