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文档之家› 皮下脂膜炎样T细胞淋巴瘤 个例
皮下脂膜炎样T细胞淋巴瘤 个例
23.03.2022
鉴别诊断:
淋巴细胞性小叶性脂膜炎 复发性发热性结节性非化脓性脂膜炎 皮肤鼻型NK/T细胞淋巴瘤 皮肤原发性CD30+间变性T细胞淋巴瘤 皮肤T细胞淋巴瘤 血管中心性T细胞淋巴瘤 皮肤蕈样肉芽肿
23.03.2022
治疗及预后:
SPTCL的治疗以联合化疗、局部放疗及生物治 疗等为主,但疗效并不满意。
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23.03.2022
特殊染色:
抗酸(-),PAS (-),六胺银(-)
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免疫组化结果:
CD8(+), CD3(+), CD45RO(+), CD4(-); CD20(散在+), CD79a(散在+); CD68(+); CD30(少数细胞+); TIA-1(+), CD56(+),PNF(+) ,GZB(+),Alk(-); Ki67(+阳性指数约为40%)
23.03.2022
WHO于2005年把SPTCL正式定义为:原 发于皮下的细胞毒性T细胞淋巴瘤,病变的皮 下组织有大小不等的多形性T细胞和大量巨噬 细胞浸润,主要累及双下肢,多伴有噬血细 胞综合征(HPS)。
23.03.2022
临床表现:
可发生于任何年龄,但以中青年为主。 好发于四肢和躯干,尤以双下肢最为常见,也可累及面部、 颈部、腋窝、腹股沟及臀部。 主要表现为非特异性单发或多发暗红色或棕褐色皮下结节 或斑块,部分患者可出现溃疡。 常伴有全身症状和体征,如发热、疲劳、肌痛、体重减轻 等。 约1/3的患者伴有HPS,表现为贫血、粒细胞减少、血小 板减少或全血细胞减少。
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23.03.2022
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