Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Others
信号通路:
Synthases/Synthetases
DL-[14C]-alpha-AA autoradiograms conducted in the presence of D- or L-alpha-AA suggested a stereospecificity of astroglial L-alpha-AA uptake. Both the uptake of alpha-AA by astrocytes and alpha-AA-induced gliotoxicity were sodium dependent [1]. Another study found that the L-isomer of alpha aminoadipate was able to competitively inhibit the transport protein, whereas the D-isomer of alpha aminoadipate was ineffective. Moreover, it was found that L-alpha aminoadipate was a competitive inhibitor of both glutamine synthetase, and gamma-glutamylcysteine synthetase. In constrast, the D-isomer of alpha aminoadipate was a far weaker inhibitor of either enzyme [2]. In vivo: Animal study showed that L-a-aminoadipic acid could lower the levels of endogenous extracellular kynurenic acid in the hippocampus in a dose-dependent fashion), though the effect of L-a-aminoadipic acid seemed to be less pronounced than its reduction of de novo produced kynurenic acid [3]. Clinical trial: So far, no clinical study has been conducted. 参考文献:
产品说明书
化学性质
产品名: L-α-Aminoadipic Acid 修订日期: 6/30/2016
Hale Waihona Puke 产品名: Cas No.: 分子量: 分子式: 别名: 化学名: SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
L-α-Aminoadipic Acid
1118-90-7
161.2
//struct//
产品描述:
Ki value of 209 μM L-α-Aminoadipic Acid is a glutamine synthetase inhibitor. Glutamine synthetase is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. In vitro: Previous study found that DL- and L-alpha-aminoadipic acid (alpha-AA) were specific gliotoxins in vitro. HPLC analysis of cultures incubated with D- or L-alpha-AA and
C6H11NO4
(S)-2-Aminohexanedioic Acid
2S-amino-hexanedioic acid
OC(CCC[C@H](N)C(O)=O)=O
Soluble in DMSO
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
ApexBio Technology
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