细胞因子及其应用
Concept of cytokine
Cytockines are low-molecular-weight regulatory proteins or glycoproteins secreted by white blood cells and various cells (vascular endothelial cell, epidermic cell and fibroblast ) in body in response to a number of stimuli.
The cytokines that stimulate hemopoietic cells to form cell colony, Participate hemopoietic function are
called CSF, for example GM-CSF,G-CSF,M-CSF, Epo,Tpo.
virus
infection
cell
IFN-α, IFN-β
IFN-α
IFN-β
The anti-virus mechanism of IFN-γ
viral replication
Inhibition of viral replication
IFN-induced protein
IFN-γ
Microbes
Mycobacterium tuberculosis (Mtb)
4. Tumor necrosis factor, TNF
The cytokines that induce directly apoptosis of tumor cells, including TNFα, TNFβ (Lymphotoxin, T), FASL, CD70L, CD30L, CD40L, OX40L, TRAIL (TNF related apoptosis-inducing ligand)
vascular endothelial growth factor (VEGF)
Epidermal growth factor
Vascular endothelial growth factor (VEGF)
Growth factors applied to angiogenesis
VEGF promotes Tumor Angiogenesis
APC
naive CD4+ T cells
Proliferation and differentiation
IFN-γ
Macrophage activation (enhanced microbial killing )
Effector T cell
IFNγ ( type II )
The anti-Mtb mechanism of IFN- γ
Biological effects
一、细胞因子的分类和功能
1. interleukin, IL （白细胞介素） 2. colony stimulating factor,CSF（集落刺激因子） 3. interferon,IFN（干扰素） 4. tumor necrosis factor,TNF （肿瘤坏死因子） 5. Chemokine, CK （趋化因子） 6. growth factor,GF （生长因子）
TNF and inflammation
5. Growth factor
The cytokines that promote growth of various
cells, epidermal growth factor，insulin-like growth factor，vascular endothelial growth factor, transforming growth factor.
GM-CSF
G-CSF
The functions of CSF
3. Interferon,IFN
The cytokຫໍສະໝຸດ nes that resist viral infection, and
interfere viral replication, including IFN-α,
IFN-β ( type I ); IFN-γ ( type II )
macrophage
Mj
IL-1
Inducing stimulus
Cytokine gene
Cytokineproducing
cell
Cytokine
Receptor
signal
Gene activation
Overview of the induction and function of Cytokine
Target cell activation inflammation
A cancerous tumor in a mouse injected with endotoxin (left) shows hemorrhagic necrosis, unlike a tumor in an untreated mouse (right). Endotoxin induces the production of TNF, which then acts to destroy the tumor.
1. Interleukin, IL
Interleukins are secreted by some leukocytes and
act upon other leukocytes, IL-1-IL-38 have
been identified.
IL-4
IL-2 IL-13
2. Colony stimulating factor, CSF
(1)Cytokines of the TNF Family Can Be Soluble or Membrane Bound
TNF-α
FASL
(2)TNF Receptors
TNF-α
TNF-TNFR2 complex. Green: TNF; Blue: TNFR2
Target cell apoptosis
Function of the lymphatic vasculature in health and disease