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synthesis ethanolamine
• Ergosterol h
• Penicillins • Vansomycin 15
Antimicrobial Agent
Introduction Definitions and Characteristics
Antimicrobial Agents
——General Considerations
Medical school of Nankai University Jingling zhang and Jing Li
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Antimicrobial Agents
目的 了解化学治疗的含义及抗菌药的发 展简史。掌握有关抗菌药物的常用 术语和各类抗菌药物的抗菌作用原 理，细菌耐药性产生的机制。
Antimicrobial mechanisms Resistance to antimicrobial drugs
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Resistance to antimicrobial drugs
HERE
Classification of drug resistance Mechanisms of drug resistance Origin of drug resistance Cross-resistance • Intrinsic resistance
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HERE
The term aInntibtirooticds uincclutdioe nsynthetic
antibacterial agents, such as the
2s.ulAfonntai-minidfesctaivned aqugiennotlosnaerse, wchiecmh ical aresunobtstparondcuecststhoaf tmcicarnobkeilsl.or suppress
Antimicrobial mechanisms Resistance to antimicrobial drugs
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Antimicrobial mechanisms
HERE
For a majority of antimicrobial drugs, the mechanism of action is not completely understood.
the growth of microorganisms.
3. Antibiotics are soluble compounds that are derived from certain microorganisms and that inhibit the growth of other microorganisms.
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Antimicrobial Agent
Introduction Definitions and Characteristics
Inhibition•oA•fmTprpirmhoeottteheironipcisrniymBn→th(e-)sdisihydrofolic (ie. inhibi••tioCNnoylsiostatfitnitnranslationaciadnrdBeadcuictrtaacsien transcript•ioPnoloymf gyxeinnsetic mater•iaCle)phalosporins
& tetracyclines. ah minoglycosides. 10
HERE Definitions and Characteristics
MPAICE ：(postantibiotic
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Antimicrobial mechanisms Resistance to antimicrobial drugs
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HERE
Introduction
1. Chemotherapeutic agents are chemicals (either natural or synthetic) used to inhibit the growth of malignant or cancerous cells within the body & to be toxic for the infectious organism but innocuous for the host.
Antimicrobial activity
Antibiotic spectrum MIC MBC PAE
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HERE Ds
The e•ffeCchtievmeniceaslsporfopaenrttimiesicrobial agent•s uMseucahllaynriesmliesofoancatiobniochemical or ph•ysiPohloagrmic odcifofkeirneentcicesbetween the host a•ndSptehcetrpuamrasoiftea.ctivity
HERE
•Lincomycins (50S)
•Quinolone•sTe→traBcloycklinaecstio(3n0oSf) DNA
•Amignyorgalsyecosides (30S)
Inhibition o•fPcyerilml wetahallmsiynnethesis
Alteration in•Rtihfaempoepirnm→e(a-)bDiliNtyA-odef pendent ctrealnl mspeomrtbarca•SrnoueslfsoonrcaeamlclitdmievsRee→mNA(sb-y)prnaodtnlihyheemytdaersroaepsteeroate
• Acquired resistance
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Resistance to antimicrobial drugs
—— Mechanisms of drug resistance
HERE
There are many different mechanisms by which microorganisms might exhibit resistance to drugs.
Erythromycin, Clindamycin and Vancomycin,
etc.
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Antimicrobial Agent
Introduction Definitions and Characteristics
Antimicrobial mechanisms Resistance to antimicrobial drugs
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HERE
Introduction
The major groups of antibacterial agents include:
Sulfonamides
Penicillins and Cephlosporines (betalactams)
Aminoglycosides
Tetracyclines and Chloramphrnicol
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HERE Definitions and Characteristics TIhteTimhteprmelifefdescettshciasritbeths e
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